Results 61 to 70 of about 51,195 (186)

Competition and cooperation among receptor tyrosine phosphatases control motoneuron growth cone guidance in Drosophila [PDF]

, 1997
The neural receptor tyrosine phosphatases DPTP69D, DPTP99A and DLAR are involved in motor axon guidance in the Drosophila embryo. Here we analyze the requirements for these three phosphatases in growth cone guidance decisions along the ISN and SNb ...
Desai, Chand J., Krueger, Neil X., Saito, Haruo, Zinn, Kai   +3 more
core  

Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. [PDF]

, 2003
Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in ...
Cheresh, David A, Frausto, Ricardo, Hood, John D, Kiosses, William B, Schwartz, Martin A   +4 more
core   +1 more source

ITIH5 as a multifaceted player in pancreatic cancer suppression, impairing tyrosine kinase signaling, cell adhesion and migration

Molecular Oncology
Inter‐alpha‐trypsin inhibitor heavy chain 5 (ITIH5) has been identified as a metastasis suppressor gene in pancreatic cancer. Here, we analyzed ITIH5 promoter methylation and protein expression in The Cancer Genome Atlas (TCGA) dataset and three tissue ...
Jennifer Kosinski, Antonio Sechi, Johanna Hain, Sophia Villwock, Stefanie Anh Ha, Maximilian Hauschulz, Michael Rose, Florian Steib, Nadina Ortiz‐Brüchle, Lara Heij, Sanne L. Maas, Emiel P. C. van derVorst, Thomas Knoesel, Annelore Altendorf‐Hofmann, Ronald Simon, Guido Sauter, Jan Bednarsch, Danny Jonigk, Edgar Dahl   +18 more
doaj   +1 more source

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source

Role of the tyrosine kinase pyk2 in the integrin-dependent activation of human neutrophils by TNF [PDF]

, 1999
Secretion of inflammatory products from neutrophils can be induced by a combination of signals from ligated integrins and receptors for soluble, physiological agonists such as TNF.
Michele Fuortes, Maxine Melchior, Hyunsil Han, Gholson J. Lyon, Carl Nathan, Nathan, Nathan, Nathan, Graham, Fuortes, Fuortes, Berton, Yan, Fernandez, Berton, Lowell, Yan, Schaller, Hanks, Fernandez, Lev, Sasaki, Avraham, Schaller, Zheng, Tokiwa, Shiloh, Jones, Loike, Hildebrand, Salgia, Hiregowdara, Li, Ganju, Ostergaard, Laudanna, Hanke, Lindberg, Ding, Jones, Klippel, Didichenko, Yan, Bilder   +43 more
core   +1 more source

Peptide Bbeta(15-42) preserves endothelial barrier function in shock [PDF]

, 2009
Loss of vascular barrier function causes leak of fluid and proteins into tissues, extensive leak leads to shock and death. Barriers are largely formed by endothelial cell-cell contacts built up by VE-cadherin and are under the control of RhoGTPases. Here
Atrasheuskaya, Alena, Bukin, Eugenij, Friedl, Peter, Gröger, Marion, Hofer-Warbinek, Renate, Ignatyev, George, Knapp, Sylvia, Matt, Ulrich, Pasteiner, Waltraud, Petzelbauer, Peter, Reingruber, Sonja, Zacharowski, Kai, Zinkl, Daniela   +12 more
core  

GBM heterogeneity as a function of variable epidermal growth factor receptor variant III activity. [PDF]

, 2016
Abnormal activation of the epidermal growth factor receptor (EGFR) due to a deletion of exons 2-7 of EGFR (EGFRvIII) is a common alteration in glioblastoma (GBM). While this alteration can drive gliomagenesis, tumors harboring EGFRvIII are heterogeneous.
David James, C, Engler, Jane R, Ewald, Andrew J, Gong, Henry, Huillard, Emmanuelle, Koshkakaryan, Gayane, Lindberg, Olle R, McKinney, Andrew, Molinaro, Annette M, Phillips, Joanna J, Robinson, Aaron E, Shieh, Joseph T   +11 more
core   +1 more source

Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion

BMC Cancer, 2009
Background Focal adhesion kinase (FAK) and Src are protein tyrosine kinases that physically and functionally interact to facilitate cancer progression by regulating oncogenic processes such as cell motility, survival, proliferation, invasiveness, and ...
Gelman Irwin H, Bu Yahao, Sachdev Sanjay
doaj   +1 more source

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. [PDF]

, 2004
Daily phagocytosis by the retinal pigment epithelium (RPE) of spent photoreceptor outer segment fragments is critical for vision. In the retina, early morning circadian photoreceptor rod shedding precedes synchronized uptake of shed photoreceptor ...
Brodie, Scott E, Finnemann, Silvia C, Huang, Xiaozhu, Kim, Yoonhee, Nandrot, Emeline F, Sheppard, Dean   +5 more
core   +1 more source

Targeting Btk/Etk of prostate cancer cells by a novel dual inhibitor. [PDF]

, 2014
Btk and Etk/BMX are Tec-family non-receptor tyrosine kinases. Btk has previously been reported to be expressed primarily in B cells and has an important role in immune responses and B-cell malignancies.
Bhardwaj, G, Changou, C, Chintapalli, S, Evans, CP, Guo, W, Kumaresan, P, Kung, H-J, Lam, KS, Liu, R, Ma, A-H, Mazloom, A, Patterson, R, Sanchez, E, Xiao, K, Xiao, W, Yang, JC, Yeh, C-T   +16 more
core   +2 more sources