Results 1 to 10 of about 50,170 (215)

Spatial transcriptomics in focal cortical dysplasia type IIb [PDF]

Acta Neuropathologica Communications
Focal cortical dysplasia (FCD) type IIb (FCD IIb) is an epileptogenic malformation of the neocortex that is characterized by cortical dyslamination, dysmorphic neurons (DNs) and balloon cells (BCs).
Yujiao Wang, Yihe Wang, Linai Guo, Chunhao Shen, Yongjuan Fu, Penghu Wei, Yongzhi Shan, Qian Wu, Yue-Shan Piao, Guoguang Zhao   +9 more
doaj   +3 more sources

Focal cortical dysplasia: Updates

Indian Journal of Pathology and Microbiology, 2022
Focal cortical dysplasias (FCDs) represent the third most frequent cause of drug-resistant focal epilepsy in adults (after hippocampal sclerosis and tumours) submitted to surgery, and the most common in the pediatric age group.
Jorge Pinheiro, Mrinalini Honavar
doaj   +3 more sources

Diffusion tensor imaging discriminates focal cortical dysplasia from normal brain parenchyma and differentiates between focal cortical dysplasia types

Insights into Imaging, 2023
Key points 1. DTI derived indices may be a useful tool for FCD characterisation. 2. FA and MD discriminated between FCD and contralateral brain parenchyma (CBP). 3. Status epilepticus increased the FA difference values between FCD and CBP. 4.
Antonio Giulio Gennari, Dorottya Cserpan, Ilona Stefanos-Yakoub, Raimund Kottke, Ruth O’Gorman Tuura, Georgia Ramantani   +5 more
doaj   +2 more sources

Single-cell genotyping and transcriptomic profiling of mosaic focal cortical dysplasia. [PDF]

Nat Neurosci
Focal cortical dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy. FCDII arises from developmental somatic activating mutations in mTOR pathway genes, leading to focal cortical dyslamination and abnormal cytomegalic cells ...
Baldassari S, Klingler E, Teijeiro LG, Doladilhe M, Raoux C, Roig-Puiggros S, Bizzotto S, Couturier J, Gilbert A, Sami L, Ribierre T, Aronica E, Adle-Biassette H, Chipaux M, Jabaudon D, Baulac S.   +15 more
europepmc   +2 more sources

MRI of focal cortical dysplasia [PDF]

Neuroradiology, 2021
AbstractFocal cortical dysplasia (FCD) are histopathologically categorized in ILAE type I to III. Mild malformations of cortical development (mMCD) including those with oligodendroglial hyperplasia (MOGHE) are to be integrated into this classification yet. Only FCD type II have distinctive MRI and molecular genetics alterations so far.
Horst Urbach, Elias Kellner, Nico Kremers, Ingmar Blümcke, Theo Demerath   +4 more
openaire   +5 more sources

Mapping Functional Connectivity Signatures of Pharmacoresistant Focal Cortical Dysplasia-Related Epilepsy. [PDF]

Ann Neurol
To determine common network alterations in focal cortical dysplasia pharmacoresistant epilepsy (FCD‐PRE) using functional connectivity analysis of resting‐state functional magnetic resonance imaging (rsfMRI).
Xie H, Illapani VSP, Vezina LG, Gholipour T, Oluigbo C, Gaillard WD, Cohen NT.   +6 more
europepmc   +2 more sources

Detection of Epileptogenic Focal Cortical Dysplasia Using Graph Neural Networks: A MELD Study.

JAMA Neurol
Importance A leading cause of surgically remediable, drug-resistant focal epilepsy is focal cortical dysplasia (FCD). FCD is challenging to visualize and often considered magnetic resonance imaging (MRI) negative.
Ripart M, Spitzer H, Williams LZJ, Walger L, Chen A, Napolitano A, Rossi-Espagnet C, Foldes ST, Hu W, Mo J, Likeman M, Rüber T, Caligiuri ME, Gambardella A, Guttler C, Tietze A, Lenge M, Guerrini R, Cohen NT, Wang I, Kloster A, Pinborg LH, Hamandi K, Jackson G, Tortora D, Tisdall M, Conde-Blanco E, Pariente JC, Perez-Enriquez C, Gonzalez-Ortiz S, Mullatti N, Vecchiato K, Liu Y, Kalviainen R, Sokol D, Shetty J, Sinclair B, Vivash L, Willard A, Winston GP, Yasuda C, Cendes F, Shinohara RT, Duncan JS, Cross JH, Baldeweg T, Robinson EC, Iglesias JE, Adler S, Wagstyl K, MELD FCD writing group.   +50 more
europepmc   +2 more sources

Multiparametric Characterization of Focal Cortical Dysplasia Using 3D MR Fingerprinting. [PDF]

Ann Neurol
To develop a multiparametric machine‐learning (ML) framework using high‐resolution 3 dimensional (3D) magnetic resonance (MR) fingerprinting (MRF) data for quantitative characterization of focal cortical dysplasia (FCD).
Su TY, Choi JY, Hu S, Wang X, Blümcke I, Chiprean K, Krishnan B, Ding Z, Sakaie K, Murakami H, Alexopoulos AV, Najm I, Jones SE, Ma D, Wang ZI.   +14 more
europepmc   +2 more sources

Focal cortical dysplasia lesion segmentation using multiscale transformer [PDF]

Insights into Imaging
Objectives Accurate segmentation of focal cortical dysplasia (FCD) lesions from MR images plays an important role in surgical planning and decision but is still challenging for radiologists and clinicians.
Xiaodong Zhang, Yongquan Zhang, Changmiao Wang, Lin Li, Fengjun Zhu, Yang Sun, Tong Mo, Qingmao Hu, Jinping Xu, Dezhi Cao   +9 more
doaj   +2 more sources

Focal Cortical Dysplasia [PDF]

Seminars in Neurology, 2015
Focal cortical dysplasias are common malformations of cerebral cortical development and are highly associated with medically intractable epilepsy. They have been classified into neuropathological subtypes (type Ia, Ib, IIa, IIb, and III) based on the severity of cytoarchitectural disruption--tangential or radial dispersion, or loss of laminar structure-
N.K Focke, M. Thom
openaire   +3 more sources