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Why Malformations of Cortical Development Cause Epilepsy [PDF]
Frontiers in Neuroscience, 2019 Malformations of cortical development (MCDs), a complex family of rare disorders, result from alterations of one or combined developmental steps, including progenitors proliferation, neuronal migration and differentiation.
Alfonso Represa
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Definitions and Classification of Malformations of Cortical Development: Practical Guidelines [PDF]
Brain, 2020 Malformations of cortical development are a group of rare disorders commonly manifesting with developmental delay, cerebral palsy or seizures. The neurological outcome is extremely variable depending on the type, extent and severity of the malformation ...
Ivana Pogledic +2 more
exaly +8 more sources
Using cortical organoids to understand the pathogenesis of malformations of cortical development [PDF]
Frontiers in NeuroscienceMalformations of cortical development encompass a broad range of disorders associated with abnormalities in corticogenesis. Widespread abnormalities in neuronal formation or migration can lead to small head size or microcephaly with disorganized ...
Kellen D. Winden +2 more
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Malformations of cortical development: Fetal imaging and genetics [PDF]
Molecular Genetics & Genomic MedicineBackground Malformations of cortical development (MCD) are a group of congenital disorders characterized by structural abnormalities in the brain cortex.
Lin‐Lin Wang +10 more
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Malformations of cortical development: genetic mechanisms and diagnostic approach [PDF]
Korean Journal of Pediatrics, 2017 Malformations of cortical development are rare congenital anomalies of the cerebral cortex, wherein patients present with intractable epilepsy and various degrees of developmental delay. Cases show a spectrum of anomalous cortical formations with diverse
Jeehun Lee
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The response to anti-seizure medications and the development of pharmacoresistant epilepsy in malformations of cortical development [PDF]
BMC MedicineBackground Malformations of cortical development (MCD) are a group of congenital brain malformation disorders commonly associated with pharmacoresistant epilepsy (PRE). While studies often focus on surgery outcomes, the pharmacological treatment is still
Pu Miao +10 more
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Language Dominance in Patients With Malformations of Cortical Development and Epilepsy [PDF]
Frontiers in Neurology, 2019 Background: Language function may be reorganized in patients with malformations of cortical development (MCD). This prospective cohort study aimed in assessing language dominance in a large group of patients with MCD and epilepsy using functional MRI ...
Giorgi Kuchukhidze +17 more
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Neurobiology of Disease, 2014 Developmental cortical malformations are associated with a high incidence of drug-resistant epilepsy. The underlying epileptogenic mechanisms, however, are poorly understood. In rodents, cortical malformations can be modeled using neonatal freeze-lesion (
Jamie Maguire +2 more
exaly +3 more sources
Significance of Polyspikes on Electroencephalography in Children with Focal Epilepsy [PDF]
Annals of Child Neurology, 2022 Purpose Epilepsy is one of the most common neurological disorders in both adults and children. After detailed history-taking, electroencephalography (EEG) is the most important investigation in the evaluation of epilepsy patients.
Ara Ko +6 more
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Residência Pediátrica, 2023 Periventricular nodular heterotopia (PH) results from abnormal neuronal migration during the genesis of the central nervous system, especially in the fetal period. It is asymptomatic in the neonatal period, however, is often characterized as epileptiform
Bruno Antunes Contrucci +6 more
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