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Focal cortical dysplasia: Updates
Indian Journal of Pathology and Microbiology, 2022 Focal cortical dysplasias (FCDs) represent the third most frequent cause of drug-resistant focal epilepsy in adults (after hippocampal sclerosis and tumours) submitted to surgery, and the most common in the pediatric age group.
Jorge Pinheiro, Mrinalini Honavar
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Brain Sciences, 2023 Objectives: The purpose of this research was to investigate whether MRI and Simultaneous Hybrid PET/MRI images were consistent in the histological classification of patients with focal cortical dysplasia. Additionally, this research aimed to evaluate the
Ning Wang +11 more
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Machine learning-based lateralization and localization of seizure onset in focal cortical dysplasia patients using ictal scalp EEG [PDF]
Frontiers in NeuroscienceInroductionThis study aimed to develop and evaluate a machine learning framework for classifying seizure onset zone lateralization and localization in patients with focal cortical dysplasia using ictal scalp electroencephalography (EEG).MethodsWe ...
Youmin Shin +13 more
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Quantifying extra‐lesional interhemispheric cortical asymmetry in focal cortical dysplasia type II [PDF]
Epilepsia OpenObjective Focal cortical dysplasia type II (FCDII) is a cortical malformation representing a common cause of surgically treatable drug‐resistant epilepsy.
Faezeh Heidari +3 more
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Limbic network co‐localization predicts pharmacoresistance in dysplasia‐related epilepsy
Annals of Clinical and Translational Neurology, 2023 To evaluate the role of focal cortical dysplasia co‐localization to cortical functional networks in the development of pharmacoresistance. One hundred thirty‐six focal cortical dysplasia patients with 3.0 T or 1.5 T MRI were identified from clinical ...
Nathan T. Cohen +7 more
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An integrated genetic analysis of epileptogenic brain malformed lesions
Acta Neuropathologica Communications, 2023 Focal cortical dysplasia is the most common malformation during cortical development, sometimes excised by epilepsy surgery and often caused by somatic variants of the mTOR pathway genes.
Atsushi Fujita +33 more
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Malformation of the Cortical Development Associated with Severe Clusters of Epileptic Seizures
Veterinary Sciences, 2022 Three cases of the malformation of the cortical development are described: a mixed breed dog and a Border Collie pup with a focal and diffuse cortical dysplasia, respectively, and a kitten with lissencephaly. All cases presented with intractable epilepsy
Aurora Cocchetto +3 more
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mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy
Neurobiology of Disease, 2023 The mechanistic target of rapamycin (mTOR) signaling pathway is an essential regulator of numerous cellular activities such as metabolism, growth, proliferation, and survival.
Anna Gerasimenko +2 more
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Problems of diagnosing focal cortical dysplasia
Эпилепсия и пароксизмальные состояния, 2021 Focal cortical dysplasia (FCD) is one of the most common causes in developing pharmacoresistant epilepsy. We present the clinical case of the patient with generalized seizures.
K. D. Yakovleva +2 more
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The changing landscape in epilepsy imaging: Unmasking subtle and unique entities
Diagnostic and Interventional Radiology, 2022 Dramatic changes have occurred recently in the field of epilepsy, including a fundamental shift in the etiology of epileptogenic substrates found at surgery. Hippocampal sclerosis is no longer the most common etiology found at epilepsy surgery and this
Mehmet E. Adin +5 more
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