Results 41 to 50 of about 174,337,571 (166)
Deep learning models for detection of malformations of cortical development in MRI
, 2020 Convolutional neural networks trained on the malformations of cortical development dataset.
Ivan Sanchez Fernandez (6517601) +1 more
core +1 more source
Cortical malformations : lessons in human brain development [PDF]
, 2020 Creating a functional cerebral cortex requires a series of complex and well-coordinated developmental steps. These steps have evolved across species with the emergence of cortical gyrification and coincided with more complex behaviors.
Calcagnotto, Maria Elisa +3 more
core +2 more sources
The changing landscape in epilepsy imaging: Unmasking subtle and unique entities
Diagnostic and Interventional Radiology, 2022 Dramatic changes have occurred recently in the field of epilepsy, including a fundamental shift in the etiology of epileptogenic substrates found at surgery. Hippocampal sclerosis is no longer the most common etiology found at epilepsy surgery and this
Mehmet E. Adin +5 more
doaj +1 more source
Neurobiology of Disease, 2022 Objectives: Malformations of cortical development (MCDs) are common causes of drug-resistant epilepsy. The mechanisms underlying the associated epileptogenesis and ictogenesis remain poorly elucidated. EEG can help in understanding these mechanisms.
Lubna Shakhatreh +9 more
doaj +1 more source
The Role of Prenatal Neurosonography in Identification of Tubulinopathy—Narrative Review
LifeTubulinopathies are severe, non-progressive neurodevelopmental disorders caused by mutations in tubulin genes, leading to profound intellectual disability, drug-resistant epilepsy, motor impairment, and lifelong dependence on care.
Krzysztof Berbeka +5 more
doaj +1 more source
Glioblastoma Multiforme in a Patient with Isolated Hemimegalencephaly
Journal of Neurological Surgery Reports, 2015 We present an exceptional case of a patient with hemimegalencephaly and secondary intractable epilepsy treated with vagus nerve stimulation (VNS) and subsequent glioblastoma development in the hemimegalencephalic hemisphere 6 years after surgery. VNS (at
Jan Chrastina +3 more
doaj +1 more source
Seizure Outcome after Hemispherectomy
Pediatric Neurology Briefs, 2001 MRI features of hemispheric malformations of cortical development (MCD) were correlated with post-hemispherectomy seizure outcome in 13 children treated at The Cleveland Clinic Foundation, OH.
J Gordon Millichap
doaj +1 more source
Acta Neuropathologica Communications, 2021 Focal malformations of cortical development (MCD) are linked to somatic brain mutations occurring during neurodevelopment. Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a newly recognized clinico ...
Thomas Bonduelle +14 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2020 Cortical development is a very complex process in which any temporal or spatial alterations can give rise to a wide range of cortical malformations. Among those malformations, periventricular heterotopia (PH) is characterized by clusters of neurons that ...
Ane Cristina Ayo-Martin +5 more
doaj +1 more source
Structures of human dynein in complex with the lissencephaly 1 protein, LIS1
eLife, 2023 The lissencephaly 1 protein, LIS1, is mutated in type-1 lissencephaly and is a key regulator of cytoplasmic dynein-1. At a molecular level, current models propose that LIS1 activates dynein by relieving its autoinhibited form.
Janice M Reimer +3 more
doaj +1 more source