Results 171 to 180 of about 50,276 (321)
Epilepsia Open, EarlyView.Abstract Objective To assess the feasibility, technical performance, and safety of a novel endovascular electroencephalogram (eEEG) electrode, EP‐01, designed for minimally invasive seizure localization in patients with drug‐resistant epilepsy. Methods This single‐center, prospective, exploratory trial enrolled five patients with drug‐resistant ...
Kota Araki +9 more
wiley +1 more source
Microelectrode array scaled for human hippocampal slices
Epilepsia Open, EarlyView.Abstract Objective Temporal lobe epilepsy (TLE) is characterized by recurrent seizures originating usually from the hippocampus, and approximately one‐third of TLE patients remain refractory to pharmacological interventions. Surgical resection offers a potential cure for refractory TLE cases, with approximately 70% achieving seizure freedom. Still, the
Anssi Pelkonen +16 more
wiley +1 more source
Neuroimaging techniques in epilepsy [PDF]
, 2010 Objective: To review state-of-the-art neuroimaging modalities in epilepsy and their clinical applications. Data sources and study selection: PubMed literature searches to March 2010, using the following key words: 'epilepsy', 'positron emission ...
Ho, WY +4 more
core
Does having bad epilepsy make you a good surgical candidate? A number needed to treat analysis
Epilepsia Open, EarlyView.Abstract Epilepsy surgery is an established treatment for drug‐resistant epilepsy, offering a realistic prospect of seizure freedom in well‐selected candidates. However, surgery is sometimes offered to individuals with a low probability of seizure freedom when it is framed as potentially “life‐saving” on the basis of the elevated mortality associated ...
Sallie Baxendale +2 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective To investigate the frequency, predictors, and clinical implications of diagnostic reassessment in patients previously diagnosed with childhood‐onset epilepsy during the transition period to adult care at a tertiary epilepsy center. Methods We conducted a retrospective cohort study of 317 patients previously diagnosed with childhood ...
Tetsuhiro Fukuyama +9 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Expanded indications, diagnostic tools, and treatment options have transformed the landscape of modern pediatric epilepsy surgery. Published real‐world experiences from large surgical cohorts are still needed. To close this gap, we evaluated access, indications, treatment, and outcomes in a contemporary pediatric epilepsy surgery ...
John R. McLaren +12 more
wiley +1 more source
Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy
Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley +1 more source
The Endothelial CXCR Family in Vascular Health and Disease
iNew Medicine, EarlyView.ABSTRACT Endothelial cells (ECs) form the dynamic interface between blood and tissue, serving as key regulators of vascular homeostasis, inflammation, and repair. Among the molecular systems governing endothelial behavior, the C‐X‐C motif chemokine receptor (CXCR) family—originally characterized in immunology for its roles in leukocyte trafficking and ...
Zhiming Wu +4 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
Enhancing Study Design and Analysis of MR Imaging Markers Through Measurement Error Modeling
Journal of Magnetic Resonance Imaging, EarlyView.ABSTRACT Background Measurement error in imaging reduces statistical power and potentially biases parameter estimation, compromising study reliability. Purpose To introduce a dual data collection design (reliability and main datasets) to quantify measurement error and apply regression calibration to correct error‐prone imaging markers, thereby ...
Xiaofeng Wang +8 more
wiley +1 more source