Results 181 to 190 of about 713,420 (262)

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

CNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han, Jingxuan Xu, Yuntian Shen, Jitai Zhang, Xia Li, Xinlei Yao, Lei Qi, Hualin Sun   +7 more
wiley   +1 more source

Bi‐Model Deep Learning Architectures: A Systematic Review of Fusion Strategies and Design Taxonomies

Concurrency and Computation: Practice and Experience, Volume 38, Issue 21, November 2026.
ABSTRACT Bi‐model deep learning, the coordinated use of two complementary models or modalities, has emerged as a powerful paradigm for improving predictive accuracy and robustness in complex real‐world applications. However, existing research remains scattered across domain‐specific studies, with no unified account of the architectural patterns, fusion
Jasmin Z. K. Chu, Joel C. M. Than, Colin C. L. Tan, Ngoc Dinh Tan   +3 more
wiley   +1 more source

Deep learning-based detection of focal cortical dysplasia in children: External validation of the MELD Graph and 3D-nnUNet pipelines. [PDF]

Neuroimage Rep
Dell'Orco A, De Vita E, D'Arco F, Lange A, Rüber T, Kaindl AM, Wattjes MP, Thomale UW, Becker LL, Tietze A.   +9 more
europepmc   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

Correction: Machine learning-based lateralization and localization of seizure onset in focal cortical dysplasia patients using ictal scalp EEG. [PDF]

Front Neurosci
Shin Y, Hwang S, Lee SB, Son H, Sunwoo JS, Lee SK, Park KI, Kim YG.   +7 more
europepmc   +1 more source

Renal Neuroendocrine Tumor Mimicking Upper Tract Urothelial Carcinoma

IJU Case Reports, Volume 9, Issue 6, November 2026.
ABSTRACT Introduction Renal pelvic or peripelvic neuroendocrine tumors are rare and may radiologically mimic invasive upper tract urothelial carcinoma. Case Presentation A man in his 70s presented with two episodes of painless gross hematuria and lower urinary tract symptoms from benign prostatic hyperplasia.
Jia‐Yuh Sheu, Yun‐Sheng Wu, Jeff S. Chueh   +2 more
wiley   +1 more source

Temporal epilepsy associated with hippocampal focal cortical dysplasia. [PDF]

Surg Neurol Int
Tran TPY, Dang TK, Ton NTM, Bui THK, Tran MC, Tran NP, Truong VT.   +6 more
europepmc   +1 more source

Investigation and characterisation of genetic factors in focal cortical dysplasia

Fokāla korikāla displāzija ir viens no biežākajiem smagas bērnu epilepsijas cēloņiem, kura molekulārie un ģenētiskie faktori nav pilnībā noskaidroti. Šī darba mērķis bija raksturot fokālas kortikālas displāzijas ģenētiskos faktorus, kas izraisa galvas ...
Veite, Laura
core  

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Nandaki Keshavan, Julia Neugebauer, Marcello Bellusci, Enrico Bertini, Garry Brown, Niklas Darin, Suzanne DeBrosse, Lucy Drexler, Stefan Drexler, Gregory M. Enns, Rebecca D. Ganetzky, Kelly Gilbert, Austin Larson, Rebecca Legi, April N. Lehman, Camile Newby, Manuel Schiff, Rachel Skeath, Peter W. Stacpoole, Sarah Thompson, Emma Watt, Saskia B. Wortmann, Jirair K. Bedoyan, Shamima Rahman   +23 more
wiley   +1 more source

CX3CL1/CX3CR1 axis dysregulation contributes to epileptogenic mechanisms in focal cortical dysplasia. [PDF]

Acta Neuropathol Commun
Lei L, Yang S, Li Y, Tian J, Fang Y, Huang T, Chen S, Zhou L.   +7 more
europepmc   +1 more source