Results 41 to 50 of about 50,276 (321)
Epilepsia, 2021 Focal cortical dysplasia (FCD) is a major cause of difficult‐to‐treat epilepsy in children and young adults, and the diagnosis is currently based on microscopic review of surgical brain tissue using the International League Against Epilepsy ...
I. Blümcke +35 more
semanticscholar +1 more source
Focal Myoclonus and Cortical Dysplasia
Pediatric Neurology Briefs, 1988 Four patients aged 9 to 19 years with focal myoclonus and intractable focal motor seizures beginning at age 4 to 6 years were treated surgically at the Montreal Neurological Hospital and Institute, McGill University, Montreal, Quebec, Canada.
J Gordon Millichap
doaj +1 more source
Focal cortical dysplasia. Clinical-radiological-pathological associations
Neurología (English Edition), 2012 Introduction: The term focal cortical dysplasia (FCD) describes a particular migration disorder with a symptomatology mainly characterised by drug-resistant epileptic seizures, typical neuroradiological images, and histological characteristics, as well ...
I. Pascual-Castroviejo +7 more
doaj +1 more source
European Journal of Nuclear Medicine and Molecular Imaging, 2022 Purpose The loss of synaptic vesicle glycoprotein 2A (SV2A) is well established as the major correlate of epileptogenesis in focal cortical dysplasia type II (FCD II), but this has not been directly tested in vivo.
Yongxiang Tang +10 more
semanticscholar +1 more source
Prenatal Neurogenesis in Autism Spectrum Disorders. [PDF]
, 2016 An ever-increasing body of literature describes compelling evidence that a subset of young children on the autism spectrum show abnormal cerebral growth trajectories.
Kaushik, Gaurav +1 more
core +1 more source
Simplified Classification of Focal Cortical Dysplasia
Pediatric Neurology Briefs, 2002 Sections of cortex from 52 of 224 (23%) patients with cortical dysplasia, operated on for drug-resistant partial epilepsy, were retrospectively re-examined histologically at Niguarda Hospital, and Istituto Nazionale Neurologico ‘C. Besta’, Milan, Italy.
J Gordon Millichap
doaj +1 more source
Current Review in Basic Science: Animal Models of Focal Cortical Dysplasia and Epilepsy
Epilepsy Currents, 2022 Focal cortical dysplasia (FCD) is a malformation of cortical development that is a prevalent cause of intractable epilepsy in children. Of the three FCD subtypes, understanding the etiology and pathogenesis of FCD type II has seen the most progress owing
Lena H. Nguyen, A. Bordey
semanticscholar +1 more source
Cellular antiseizure mechanisms of everolimus in pediatric tuberous sclerosis complex, cortical dysplasia, and non-mTOR-mediated etiologies. [PDF]
, 2018 The present study was designed to examine the potential cellular antiseizure mechanisms of everolimus, a mechanistic target of rapamycin (mTOR) pathway blocker, in pediatric epilepsy cases. Cortical tissue samples obtained from pediatric patients (n
Barry, Joshua +8 more
core +2 more sources
Evidence for a Dual-Pathway, 2-Hit Genetic Model for Focal Cortical Dysplasia and Epilepsy
Neurology: Genetics, 2022 Background and Objectives The 2-hit model of genetic disease is well established in cancer, yet has only recently been reported to cause brain malformations associated with epilepsy.
M. Bennett +14 more
semanticscholar +1 more source
Intrinsic and secondary epileptogenicity in focal cortical dysplasia type II
Epilepsia, 2022 Favorable seizure outcome is reported following resection of bottom‐of‐sulcus dysplasia (BOSD). We assessed the distribution of epileptogenicity and dysplasia in and around BOSD to better understand this clinical outcome and the optimal surgical approach.
Emma Macdonald-Laurs +8 more
semanticscholar +1 more source