Results 51 to 60 of about 50,276 (321)

Identification of genetic characteristics in pediatric epilepsy with focal cortical dysplasia type 2 using deep whole‐exome sequencing

Molecular Genetics & Genomic Medicine, 2022
Focal cortical dysplasia type 2 (FCD2) is a malformation of cortical development that constitutes a common cause of pediatric focal epilepsy. Germline or somatic variants in the mammalian target of rapamycin (mTOR) signaling pathway genes are the ...
Yan Xu, R. Zhao, Min Wang, Xin-hua Wang, Yi Wang, Hao Li, Yangyang Ma, Bing-bing Wu, Yuanfeng Zhou   +8 more
semanticscholar   +1 more source

Epileptic networks in focal cortical dysplasia revealed using electroencephalography-functional magnetic resonance imaging. [PDF]

, 2011
Surgical treatment of focal epilepsy in patients with focal cortical dysplasia (FCD) is most successful if all epileptogenic tissue is resected.
Bartolomei, F, Carmichael, DW, Chaudhary, UJ, Chauvel, P, Diehl, B, Duncan, JS, Guye, M, Laufs, H, Lemieux, L, McEvoy, AW, Rodionov, R, Thornton, R, Vollmar, C, Vulliemoz, S, Walker, MC   +14 more
core   +1 more source

Dual Pathology in Rasmussen’s Encephalitis: A Report of Coexistent Focal Cortical Dysplasia and Review of the Literature

Case Reports in Pathology, 2012
Rasmussen’s encephalitis is a well-established, albeit rare cause of medically intractable epilepsy. In a small number of Rasmussen's cases, a second pathology is identified, which independently can cause medically intractable seizures (dual pathology ...
Richard A. Prayson
doaj   +1 more source

Balloon cells promote immune system activation in focal cortical dysplasia type 2b

Neuropathology and Applied Neurobiology, 2021
Focal cortical dysplasia (FCD) type 2 is an epileptogenic malformation of the neocortex associated with somatic mutations in the mammalian target of rapamycin (mTOR) pathway.
T. Zimmer, Diede W. M. Broekaart, M. Luinenburg, C. Mijnsbergen, J. Anink, N. S. Sim, I. Michailidou, F. Jansen, P. V. van Rijen, Jeong Ho Lee, Liesbeth François, J. van Eyll, S. Dedeurwaerdere, E. V. van Vliet, A. Mühlebner, J. D. Mills, E. Aronica   +16 more
semanticscholar   +1 more source

Dynamic imaging of coherent sources reveals different network connectivity underlying the generation and perpetuation of epileptic seizures [PDF]

, 2013
The concept of focal epilepsies includes a seizure origin in brain regions with hyper synchronous activity (epileptogenic zone and seizure onset zone) and a complex epileptic network of different brain areas involved in the generation, propagation, and ...
Anwar, Abdul Rauf, Deuschl, Günther, Elshoff, Lydia, Muthuraman, Muthuraman, Raethjen, Jan, Siniatchkin, Michael, Stephani, Ulrich   +6 more
core   +3 more sources

Toward a refined genotype–phenotype classification scheme for the international consensus classification of Focal Cortical Dysplasia

Brain Pathology, 2021
Focal Cortical Dysplasia (FCD) is the most common cause of drug‐resistant focal epilepsy in children and young adults. The diagnosis of currently defined FCD subtypes relies on a histopathological assessment of surgical brain tissue.
I. Blumcke, F. Cendes, H. Miyata, M. Thom, E. Aronica, I. Najm   +5 more
semanticscholar   +1 more source

A case of hippocampal sclerosis diagnosed as cortical dysplasia due to preoperative brain MRI finding [PDF]

, 2010
Hippocampal sclerosis (HS) is one of the most common features of intractable temporal lobe epilepsy. Generally it can be identified through brain magnetic resonance imaging (MRI) with high degree of sensitivity and specificity. Typical brain MRI findings
Barkovich, Baron, Bast, Bautista, Benbadis, Cendes, Choi, Dong Seok Kim, Fauser, Harvey, Harvey, Heung Dong Kim, Jackson, Jeong Tae Kim, Joon Soo Lee, Jun Seok Lee, King, Kobayashi, Koepp, Kyo Ryung Kim, Lewis, Meiners, Min Jung Choi, Mitchell, Mohamed, Moore, Ryvlin, Spencer, Stevens, Tae Seong Kim, Urbach, Young Mock Lee   +31 more
core   +1 more source

Histological Subtypes of Focal Cortical Dysplasia

Pediatric Neurology Briefs, 2008
Clinical, EEG, MRI, neuropsychological, surgical, and seizure outcome data in 200 children with histologically proven cortical malformations were analyzed in a study at Motol University Hospital, Prague, Czech Republic, Miami Children's Hospital, and ...
J Gordon Millichap
doaj   +1 more source

Deep learning-based automated lesion segmentation on pediatric focal cortical dysplasia II preoperative MRI: a reliable approach

Insights into Imaging
Focal cortical dysplasia (FCD) represents one of the most common causes of refractory epilepsy in children. Deep learning demonstrates great power in tissue discrimination by analyzing MRI data.
Siqi Zhang, Yijiang Zhuang, Yi Luo, Fengjun Zhu, Wen Zhao, Hongwu Zeng   +5 more
semanticscholar   +1 more source

Multicenter Validation of a Deep Learning Detection Algorithm for Focal Cortical Dysplasia

Neurology, 2021
Background and Objective To test the hypothesis that a multicenter-validated computer deep learning algorithm detects MRI-negative focal cortical dysplasia (FCD).
R. Gill, H. Lee, B. Caldairou, Seokjun Hong, C. Barba, F. Deleo, L. D'Incerti, V. C. Mendes Coelho, M. Lenge, M. Semmelroch, D. Schrader, F. Bartolomei, M. Guye, A. Schulze-Bonhage, H. Urbach, K. Cho, F. Cendes, R. Guerrini, G. Jackson, R. Hogan, N. Bernasconi, A. Bernasconi   +21 more
semanticscholar   +1 more source