Results 81 to 90 of about 50,276 (321)

Focal Cortical Dysplasias

Journal of the International Child Neurology Association, 2017
Focal cortical dysplasias (FCDs) are common malformations of cerebral cortical development that are highly associated with medically intractable epilepsy. FCDs have been classified according to neuropathological subtypes (type Ia, Ib, IIA, IIb, and III) based on the severity of cytoarchitectural disruption, and the presence of unique cell types (e.g ...
Ali Mahta, Peter B. Crino
openaire   +2 more sources

Fully automated detection of focal cortical dysplasia: Comparison of MPRAGE and MP2RAGE sequences

Epilepsia, 2021
The detection of focal cortical dysplasia (FCD) in magnetic resonance imaging is challenging. Voxel‐based morphometric analysis and automated FCD detection using an artificial neural network (ANN) integrated into the Morphometric Analysis Program (MAP18)
T. Demerath, C. Kaller, M. Heers, A. Staack, R. Schwarzwald, T. Kober, M. Reisert, A. Schulze-Bonhage, H. Huppertz, H. Urbach   +9 more
semanticscholar   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

Acta Neuropathologica, 2019
Genetic malformations of cortical development (MCDs), such as mild MCDs (mMCD), focal cortical dysplasia (FCD), and hemimegalencephaly (HME), are major causes of severe pediatric refractory epilepsies subjected to neurosurgery.
S. Baldassari, Théo Ribierre, Elise Marsan, H. Adle-Biassette, S. Ferrand-Sorbets, C. Bulteau, N. Dorison, M. Fohlen, M. Polivka, S. Weckhuysen, G. Dorfmüller, M. Chipaux, S. Baulac   +12 more
semanticscholar   +1 more source

Developmental disorders of vision [PDF]

, 2003
This review of developmental disorders of vision focuses on a few of the many disorders that disrupt visual development. Given the enormity of the human visual system in the primate brain and complexity of visual development, however, there are likely ...
Duchaine, BC, Galaburda, AM
core   +1 more source

miR‐135a‐5p Is a Promising Target to Prevent the Glomerulosclerosis Associated with Podocyte Developmental Toxicity in Offspring Induced by Prenatal Dexamethasone Exposure

Advanced Science, EarlyView.
Prenatal dexamethasone exposure (PDE) programs persistent podocyte developmental injury and adult glomerulosclerosis. Mechanistically, glucocorticoid receptor (GR) binds the miR‐135a‐5p promoter and recruits the histone acetyltransferase p300, increasing promoter histone acetylation and sustaining miR‐135a‐5p expression. Elevated miR‐135a‐5p suppresses
Xiaoqi Zhao, Haiyun Chen, Yanan Zhu, Zhiping Xia, Hangyuan He, Yutang Liu, Tianshu Yang, Hui Wang, Ying Ao   +8 more
wiley   +1 more source

Focal Cortical Dysplasia and Hot Water Epilepsy

Pediatric Neurology Briefs, 2004
A 4-year-old girl with complex partial seizures triggered by bathing in hot water and found to have a left parietal focal cortical dysplasia on MRI is reported from the University of Siena, Italy.
J Gordon Millichap
doaj   +1 more source

Increased expression of complement components in tuberous sclerosis complex and focal cortical dysplasia type 2B brain lesions

Epilepsia, 2021
Increasing evidence supports the contribution of inflammatory mechanisms to the neurological manifestations of epileptogenic developmental pathologies linked to mammalian target of rapamycin (mTOR) pathway dysregulation (mTORopathies), such as tuberous ...
Victoria E Gruber, M. Luinenburg, Katrin Colleselli, V. Endmayr, J. Anink, T. Zimmer, F. Jansen, P. Gosselaar, R. Coras, T. Scholl, I. Blumcke, J. Pimentel, J. Hainfellner, R. Höftberger, K. Rössler, M. Feucht, J. van Scheppingen, E. Aronica, A. Mühlebner   +18 more
semanticscholar   +1 more source

Computational brain anatomy in patients with temporal lobe epilepsy [PDF]

, 2014
BACKGROUND Temporal lobe epilepsy (TLE) is a frequent type of focal epilepsy that constitutes 30% to 50% of all epileptic syndromes. This medical condition is often associated with hippocampal sclerosis, however it can be due to cortical dysplasia, brain
WEATHERILL, G.
core  

Atypical focal cortical dysplasia in a patient with Cowden syndrome [PDF]

, 2014
published_or_final_versio
Chan, YK, Cheung, KM, Lam, CW, Siu, CWK, Yong, L   +4 more
core   +1 more source