Results 101 to 110 of about 506,213 (249)
Dynamic Mechanisms of Neocortical Focal Seizure Onset
PLoS Computational Biology, 2014 Recent experimental and clinical studies have provided diverse insight into the mechanisms of human focal seizure initiation and propagation. Often these findings exist at different scales of observation, and are not reconciled into a common understanding. Here we develop a new, multiscale mathematical model of cortical electric activity with realistic
Wang Y, Goodfellow M, Taylor PN, Baier G
openaire +6 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Study of the fracture process of Al Hoceima earthquake (24/02/2004, Mw=6.2) from regional and teleseismic data. [PDF]
, 2005 We studied the source time function (STF) and rupture process of the 2004 Alhoceima, Morocco earthquake of Mw = 6.2 using teleseismic and regional broad-band data. From regional broad-band data, STF function was determined using three large after- shocks
Bezzghoud, M +4 more
core
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Focal Mechanism and Rupture Process of 2004 Alhoceima (Morocco, Mw=6.2) Earthquake from Teleseismic and Regional Broad-Band Data. [PDF]
, 2004 We have study the focal mechanism of the 2004 Alhoceima (Morocco, Mw=6.2) earthquake using teleseismic and regional broad-band data. The solution obtained shows strike slip motion with planes striking respectively on NNE-SSW and WNW-ESE direction and ...
Bezzeghoud, M +5 more
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Focal Randomization: An optimal mechanism for the evaluation of R&D [PDF]
In most countries, governments intervene in the process of R&D by financing a substantial part of it. The mechanism employed for choosing the projects to be financed is a committee composed of experts who evaluate projects in their field of ...
Elise Brezis
core
Focal mechanism of the August 1, 1975 Oroville earthquake [PDF]
, 1976 Long-period teleseismic P and S waves from the WWSS and Canadian networks are modeled to determine the focal parameters for the main shock in the Oroville earthquake series.
Butler, Rhett, Langston, Charles A.
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source