Results 61 to 70 of about 321,758 (264)
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
, 2018 Focal adhesions are dynamic multiprotein structures connecting cells to their surrounding microenvironment. Cells receive critical mechanical signals from adhesions that control many cellular processes including wound healing, differentiation, development, and cancer.
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Molecular Mechanisms of Proteinuria in Focal Segmental Glomerulosclerosis [PDF]
Frontiers in Medicine, 2018 Focal segmental glomerulosclerosis (FSGS) is the most common primary glomerular disease resulting in end-stage renal disease in the USA and is increasing in prevalence worldwide. It is a diverse clinical entity with idiopathic, genetic, metabolic, infectious, and other causes that culminate in a characteristic histologic pattern of injury.
Yumeng Wen, Sapna Shah, Kirk N. Campbell
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FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Correlations of earthquake focal mechanisms [PDF]
Geophysical Journal International, 1992 SUMMARY We performed a statistical analysis of the Harvard catalogue of seismic moment tensor solutions. We investigated the distribution of hypocentres on focal spheres of earthquakes. The hypocentres are concentrated along fault planes; the hypocentre distribution does not significantly differ for earthquakes in different depth ranges.
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
FocoNet: Transformer‐Based Focal‐Mechanism Determination
Journal of Geophysical Research: Machine Learning and ComputationTraditional focal‐mechanism determination primarily relies on fitting the first‐motion polarities with grid‐search algorithms. We developed a machine‐learning model, FocoNet, to include more seismic information into focal mechanism determination.
Xiaohan Song +3 more
doaj +1 more source
Frontiers in Earth ScienceThe seismic attenuation relationship between ground motion parameters (such as peak acceleration and response spectra value) and seismic parameters (such as magnitude and epicentral distance) is an important foundation for seismic hazard analysis and the
Deyu Yin
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Mechanisms of Disease Reversal in Focal and Segmental Glomerulosclerosis [PDF]
Advances in Chronic Kidney Disease, 2014 It is well known that progression of chronic kidney disease can be ameliorated or stabilized by different interventions, but more studies indicate that it can even be reversed. Most data suggest that current therapy, especially renin-angiotensin system inhibition alone, is not sufficient to initiate and maintain long-term regression of glomerular ...
Hai-Chun Yang, Agnes B. Fogo
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source