Results 161 to 170 of about 6,504,407 (344)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Research development with focus groups: experience with motorcycle couriers. A research strategy

open access: yesOnline Brazilian Journal of Nursing, 2006
This paper aims at discussing some aspects of the use of focus groups as a research strategy. The discussion has grounds in the qualitative research experience carried out in order to explore the motorcycle couriers point-of-view about traffic accident ...
Andréa Márian Veronese   +1 more
doaj  

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham   +21 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Online Focus Groups: Electronic Discussions for Research

open access: yesForum: Qualitative Social Research, 2000
As part of a dissertation research project, an online focus group was created in order to help determine questions and issues to be asked in depth interviews of distance learning students about their motives, barriers and enablers in their decision to ...
Roger J. Rezabek
doaj  

But Were We Successful? Using Online Asynchronous Focus Groups to Evaluate Library Services

open access: green, 2021
Rebekah Cummings   +4 more
openalex   +1 more source

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