Results 201 to 210 of about 481,739 (319)

Spatial patterning of contractility by a self-organized mechanogen activity gradient underlies Drosophila gastrulation. [PDF]

Nat Commun
Mundhe G, Dunsing-Eichenauer V, Philippe JM, Da Silva É, Collinet C, Lecuit T.   +5 more
europepmc   +1 more source

Targeting PRKCN, an Essential Driver Orchestrating mTOR‐IRF4 Axis Independently of Kinase Activity, in Multiple Myeloma

Advanced Science, EarlyView.
Constitutive PRKCN expression is driven by super‐enhancers and modulated by NF‐κB signaling in multiple myeloma (MM). PRKCN activates mTORC1/2‐IRF4 signaling axis and favors tumor cell growth independently of its kinase activity. IRF4 reciprocally promotes PRKCN transcription, creating a feed‐forward loop.
Koukou Tang, Dongpeng Jiang, Peng Ke, Xiaosen Bian, Lili Zhang, Ying Zhang, Tingting Zhu, Weiwei Qu, Wenhui Qi, Yang Xu, Chengcheng Fu, Depei Wu, Jianhong Chu   +12 more
wiley   +1 more source

Patient-reported experiences of cognitive difficulties and their impact on daily life in narcolepsy type 1. [PDF]

Front Neurol
Maski K, Pfeiffer KM, Brod M, Latzman RD, Bermingham SL, Maruff P, Harel BT.   +6 more
europepmc   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

Advanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao, Yadong Liu, Miao Cui, Runtian Gao, Weimin Guo, Guohua Wang, Yadong Wang, Tao Jiang   +7 more
wiley   +1 more source

Widespread fog invigoration due to aerosols over Northern India. [PDF]

Sci Adv
Arun N, Sarangi C, Kanawade VP, Singh MK, Gautam R.   +4 more
europepmc   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Beyond the Leaderboard: Evaluating the Robustness of Deep Learning Models for Detecting Freezing of Gait. [PDF]

Eur J Neurosci
Salomon A, Gazit E, Shimoni N, Nisimov L, Herman T, Sandler V, Hausdorff JM.   +6 more
europepmc   +1 more source

Nanoscopic Imaging the Lithiation of Sulfur Nanoparticles under Electron Beam Irradiation

Advanced Science, EarlyView.
ABSTRACT In situ Transmission Electron Microscopy (TEM) provides powerful insights into the reaction mechanisms of Lithium‐Sulfur (Li‐S) batteries. However, distinguishing intrinsic electrochemical behaviors from artifacts induced by high‐energy electron beam irradiation remains a critical challenge.
Rui Huang, Xingyu Zhang, Xingqi Liao, Ruilin Bai, Xianqi Wu, Junlei Xiang, Sheng Cheng, Yifan Zhang, Jing Wang, Hongfa Xiang, Juyeong Kim, Qiaobao Zhang, Yu Yao, Xiaohui Song   +13 more
wiley   +1 more source

A machine learning-based short-term forecasting method for heavy fog in Anhui Province of China. [PDF]

Sci Rep
Sun Y, Wang C, Yao Y, Wang F, Zhou J, Wang X.   +5 more
europepmc   +1 more source

Encoding Cumulation to Learn Perturbative Nonlinear Oscillatory Dynamics

Advanced Science, EarlyView.
Weak nonlinearities critically shape the long term behavior of oscillatory systems but are difficult to identify from data. A data‐driven framework is introduced to infer governing equations of weakly nonlinear oscillators from sparse and noisy observations.
Teng Ma, Ting‐Ting Gao, Wei Cui, Attilio Frangi, Gang Yan, Lin Zhao   +5 more
wiley   +1 more source