Results 211 to 220 of about 101,651 (261)
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Pediatrics, 2006
No infant anywhere in the world should die from anencephaly or be paralyzed by spina bifida because he or she was conceived and developed in a folate-deficient environment.1,2 The Medical Research Council Vitamin Study Research Group's randomized, controlled trial showed in 1991 that pregnant women who consume enough synthetic folic acid before and ...
Robert L, Brent, Godfrey P, Oakley
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No infant anywhere in the world should die from anencephaly or be paralyzed by spina bifida because he or she was conceived and developed in a folate-deficient environment.1,2 The Medical Research Council Vitamin Study Research Group's randomized, controlled trial showed in 1991 that pregnant women who consume enough synthetic folic acid before and ...
Robert L, Brent, Godfrey P, Oakley
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Current Opinion in Clinical Nutrition and Metabolic Care, 2000
Hyperhomocysteinaemia has been identified from epidemiological studies as an independent risk factor for cardiovascular disease. Plasma total homocysteine is elevated in renal impairment, which may be a consequence of cardiovascular disease. However, it is also likely that plasma total homocysteine promotes cardiovascular disease, particularly through ...
Woodside, Jayne, Young, Ian
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Hyperhomocysteinaemia has been identified from epidemiological studies as an independent risk factor for cardiovascular disease. Plasma total homocysteine is elevated in renal impairment, which may be a consequence of cardiovascular disease. However, it is also likely that plasma total homocysteine promotes cardiovascular disease, particularly through ...
Woodside, Jayne, Young, Ian
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Journal of Clinical Pathology, 2011
The measurement of total folate in clinical material became possible with the introduction of the Lactobacillus casei assay some 50 years ago. The use of lactoglobulin as a folate binding agent to measure folate by radioisotope dilution, later fluorimetry, is more user friendly but gives largely similar results. The principal folate …
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The measurement of total folate in clinical material became possible with the introduction of the Lactobacillus casei assay some 50 years ago. The use of lactoglobulin as a folate binding agent to measure folate by radioisotope dilution, later fluorimetry, is more user friendly but gives largely similar results. The principal folate …
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Autoantibodies to Folate Receptors in the Cerebral Folate Deficiency Syndrome
New England Journal of Medicine, 2005In infantile-onset cerebral folate deficiency, 5-methyltetrahydrofolate (5MTHF) levels in the cerebrospinal fluid are low, but folate levels in the serum and erythrocytes are normal. We examined serum specimens from 28 children with cerebral folate deficiency, 5 of their mothers, 28 age-matched control subjects, and 41 patients with an unrelated ...
Ramaekers, Vincent +6 more
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Role of Folate Binding Proteins in Folate Metabolism
1990The essential role of folates in cellular biochemistry is well established, but the nature of the participation by folate-binding proteins has been disputed. This review will define folate-binding proteins and distinguish them from low-affinity, nonspecific folate binders and folate-dependent intracellular enzymes.
M A, Kane, S, Waxman
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Annual Review of Nutrition, 1996
Glycosyl-phosphatidylinositol-anchored folate receptors (FR) have physiologic and pharmacologic relevance in mediating cellular and transcellular folate/antifolate transport. Three FR isoforms with differing relative affinities for folates and expression patterns in normal and malignant cells/tissues are recognized, but the precise mechanism of ...
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Glycosyl-phosphatidylinositol-anchored folate receptors (FR) have physiologic and pharmacologic relevance in mediating cellular and transcellular folate/antifolate transport. Three FR isoforms with differing relative affinities for folates and expression patterns in normal and malignant cells/tissues are recognized, but the precise mechanism of ...
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Conformational analysis of folates and folate analogues
International Journal of Quantum Chemistry, 2009Conformational energy calculations have been performed on a series of folates and folate analogues, including dihydrofolate and methotrexate. A large number of conformations are energetically accessible to these molecules, and some are common to all. The conformations adopted by methotrexate, when bound to dihydrofolate reductases from various sources,
M. J. Spark +2 more
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