Results 211 to 220 of about 101,883 (259)
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Journal of Clinical Pathology, 2011
The measurement of total folate in clinical material became possible with the introduction of the Lactobacillus casei assay some 50 years ago. The use of lactoglobulin as a folate binding agent to measure folate by radioisotope dilution, later fluorimetry, is more user friendly but gives largely similar results. The principal folate …
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The measurement of total folate in clinical material became possible with the introduction of the Lactobacillus casei assay some 50 years ago. The use of lactoglobulin as a folate binding agent to measure folate by radioisotope dilution, later fluorimetry, is more user friendly but gives largely similar results. The principal folate …
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Conformational analysis of folates and folate analogues
International Journal of Quantum Chemistry, 2009Conformational energy calculations have been performed on a series of folates and folate analogues, including dihydrofolate and methotrexate. A large number of conformations are energetically accessible to these molecules, and some are common to all. The conformations adopted by methotrexate, when bound to dihydrofolate reductases from various sources,
M. J. Spark +2 more
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Annual Review of Nutrition, 1996
Glycosyl-phosphatidylinositol-anchored folate receptors (FR) have physiologic and pharmacologic relevance in mediating cellular and transcellular folate/antifolate transport. Three FR isoforms with differing relative affinities for folates and expression patterns in normal and malignant cells/tissues are recognized, but the precise mechanism of ...
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Glycosyl-phosphatidylinositol-anchored folate receptors (FR) have physiologic and pharmacologic relevance in mediating cellular and transcellular folate/antifolate transport. Three FR isoforms with differing relative affinities for folates and expression patterns in normal and malignant cells/tissues are recognized, but the precise mechanism of ...
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Role of Folate Binding Proteins in Folate Metabolism
1990The essential role of folates in cellular biochemistry is well established, but the nature of the participation by folate-binding proteins has been disputed. This review will define folate-binding proteins and distinguish them from low-affinity, nonspecific folate binders and folate-dependent intracellular enzymes.
M A, Kane, S, Waxman
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Folate, antifolates, and folate analogs in Pediatric Oncology
Investigational New Drugs, 1996M C, Hum, B A, Kamen
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