Results 41 to 50 of about 2,059 (132)
Case Reports in Pediatrics, Volume 2025, Issue 1, 2025.Congenital disorders of glycosylation (CDG) constitute a group of rare genetic metabolic diseases caused by defects in the synthesis and modification of oligosaccharides. CDG‐Ie is a rare subtype caused by mutations in the DPM1 gene. We describe a female patient who presented with ocular abnormalities, motor retardation, hypotonia, hepatic dysfunction,
Wei Song +4 more
wiley +1 more source
Interferon Stimulated Gene Expression Is a Biomarker for Primary Mitochondrial Disease
Annals of Neurology, Volume 96, Issue 6, Page 1185-1200, December 2024.Objective Mitochondria are implicated in regulation of the innate immune response. We hypothesized that abnormalities in interferon signaling may contribute to pathophysiology in patients with primary mitochondrial disease (PMD). Methods Expression of interferon stimulated genes (ISGs) was measured by real‐time polymerase chain reaction (PCR) in whole ...
Nandaki Keshavan +3 more
wiley +1 more source
Synthetic Cell Surface Receptors for Delivery of Therapeutics and Probes [PDF]
, 2012 Receptor-mediated endocytosis is a highly efficient mechanism for cellular uptake of membrane-impermeant ligands. Cells use this process to acquire nutrients, initiate signal transduction, promote development, regulate neurotransmission, and maintain ...
Hymel, David, Peterson, Blake R.
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Clinical glycoproteomics: methods and diseases
MedComm, Volume 5, Issue 10, October 2024.An overview of clinical glycoproteomics: methods and diseases. The primary types of glycosylations include N‐glycosylation and O‐glycosylation. Three main glycoproteomic strategies are employed, with the bottom‐up approach being the most commonly utilized.
Yujia Wang +3 more
wiley +1 more source
Food Science &Nutrition, Volume 12, Issue 9, Page 6442-6460, September 2024.Bifidobacterium longum BL‐19 shows promise as an adjunct therapy for NAFLD, as it can significantly improve oxidative stress, reduce inflammation in the liver, and decrease lipid accumulation. Furthermore, B. longum BL‐19 enhances the production of butyric acid in the mouse gut.
Xiajun Zhang +8 more
wiley +1 more source
ARF1 is directly involved in dynamin-independent endocytosis [PDF]
, 2008 Endocytosis of glycosylphosphatidyl inositol (GPI)-anchored proteins (GPI-APs) and the fluid phase takes place primarily through a dynamin- and clathrin-independent, Cdc42-regulated pinocytic mechanism.
Kumari, Sudha, Mayor, Satyajit
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Purification and Analysis of Folate-dye Conjugate [PDF]
, 2010 The folate receptor has achieved great importance for use in targeted drug delivery and in vitro and in vivo diagnostic assays. The folate receptor (FR) is over-expressed on several cancer cell types and activated macrophages, but exists in relatively ...
Sakhiya, Dilipkumar
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Active emulsions in living cell membranes driven by contractile stresses and transbilayer coupling
, 2022 The spatiotemporal organisation of proteins and lipids on the cell surface has direct functional consequences for signaling, sorting and endocytosis. Earlier studies have shown that multiple types of membrane proteins including transmembrane proteins ...
Anilkumar, Anupama Ambika +6 more
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Cholesterol-sensitive Cdc42 activation regulates actin polymerization for endocytosis via the GEEC pathway [PDF]
, 2007 Glycosyl-phosphatidylinositol (GPI)-anchored proteins (GPI-APs) are present at the surface of living cells in cholesterol dependent nanoscale clusters. These clusters appear to act as sorting signals for the selective endocytosis of GPI-APs via a Cdc42 ...
Chadda, Rahul +5 more
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Folate-PEG-Histidine for Use in Detection, Capture, and Analysis of FR+ Cells [PDF]
, 2016 Folate receptor alpha is a membrane-bound protein displaying high affinity for folic acid. This receptor serves as a receptor-mediated transport system of folic acid into cancer and cells associated with inflammation (e.g., macrophages).
Dwyer, Sean
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