Results 31 to 40 of about 2,059 (132)

Identification of GPI anchor attachment signals by a Kohonen self-organizing map [PDF]

, 2017
Motivation: Anchoring of proteins to the extracytosolic leaflet of membranes via C-terminal attachment of glycosylphosphatidylinositol (GPI) is ubiquitous and essential in eukaryotes.
Fankhauser, Niklaus, Mäser, Pascal
core  

LRP2 mediates folate uptake in the developing neural tube [PDF]

, 2014
The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2) is a multifunctional cell surface receptor expressed in the embryonic neuroepithelium.
Cabrera, R.M., Hammes, A., Kur, E., Mecklenburg, N., Willnow, T.E.   +4 more
core   +1 more source

Anticancer Molecular Mechanisms of Epigallocatechin Gallate: An Updated Review on Clinical Trials

Food Science &Nutrition, Volume 13, Issue 8, August 2025.
Epigallocatechin gallate (EGCG), a bioactive compound abundantly exists in green tea and grapes with strong antioxidant activity and anticancer potential is a suitable approach to reduce the cancer burden. The invitro and invivo anticancer studies of EGCG proved anticancer and anti‐tumor effect through modulation of cancer signaling pathways, reduction
Ahmad Mujtaba Noman, Muhammad Tauseef Sultan, Aimen Mazhar, Iqra Baig, Jawaria Javaid, Muzzamal Hussain, Muhammad Imran, Suliman A. Alsagaby, Waleed Al Abdulmonem, Ahmed Mujtaba, Tadesse Fenta Yehuala, Mohammed M. Ghoneim, Ehab M. Mostafa, Mohamed A. Abdelgawad   +13 more
wiley   +1 more source

Co‐Binding of Methotrexate and Cyclophosphamide via Folic Acid‐Decorated Graphene Oxide Nanomaterials for Therapeutic Approach against Breast Cancer

ChemistrySelect, Volume 10, Issue 25, July 4, 2025.
Schematic Presentation of Dual Drug‐Loaded FA‐Functionalized GO Nanosystem for Targeted Breast Cancer Therapy. Abstract In this study, we developed a graphene oxide (GO)‐based nanocarrier system co‐loaded with methotrexate (MTX) and cyclophosphamide (CP) and functionalized with folic acid (FA) for targeted drug delivery.
Reyhan Yanıkoglu, Canan Yagmur Karakas, Mert Akın Insel, Merve Sevgi, Esmahan Caglar, Hasan Berkay Abdioğlu, Yagmur Isık, Hilal Calık, Ali Can Zaman, Fatih Ciftci, Rabia Cakır, Huseyin Uvet, Cem Bulent Ustundag   +12 more
wiley   +1 more source

Soil Moisture and Its Interaction With Temperature Determine Root Metabolomes of a Himalayan Alpine Shrub

Physiologia Plantarum, Volume 177, Issue 4, July/August 2025.
ABSTRACT Climate change profoundly impacts plants. However, our understanding of plant responses to climate largely relies on plant morphology and physiology, while plant metabolomic responses, especially those within plant roots, have received much less attention.
Sayantika Banerjee, Nikita Rathore, Jaroslav Semerád, Tomáš Cajthaml, Zuzana Münzbergová, Dinesh Thakur   +5 more
wiley   +1 more source

Association of FCGR3A and FCGR3B haplotypes with rheumatoid arthritis and primary Sjögren's syndrome [POSTER PRESENTATION] [PDF]

, 2005
Background Rheumatoid arthritis (RA) is an autoimmune disease that is thought to arise from a complex interaction between multiple genetic factors and environmental triggers.
Barrett, J.H., Bowman, S.J., Conaghan, P.G., Cooper, D., Emery, P., Green, M., Haroon-Rashid, L., Isaacs, J.D., Lawson, C.A., Mackie, S., Martin, S., Morgan, A.W., Pease, C.T., Quinn, M., Robinson, J.I.   +14 more
core   +2 more sources

Colorectal Cancer: Pathogenesis and Targeted Therapy

MedComm, Volume 6, Issue 3, March 2025.
Chromosomal instability, microsatellite instability, and the CpG island methylator phenotype are key pathogenic pathways in the adenoma–carcinoma sequence of CRC. Epigenetic remodeling and metabolic reprogramming are two major hallmarks of tumor cells, demonstrating bidirectional regulatory mechanisms across various cancers, including CRC.
Jingyuan Li, Jiashu Pan, Lisheng Wang, Guang Ji, Yanqi Dang   +4 more
wiley   +1 more source

Model systems, lipid rafts, and cell membranes [PDF]

, 2000
Views of how cell membranes are organized are presently changing. The lipid bilayer that constitutes these membranes is no longer understood to be a homogeneous fluid.
Simons, Kai, Vaz, Winchil L. C.
core   +1 more source

The Significance of Mono‐ and Dual‐Effective Agents in the Development of New Antifungal Strategies

Chemical Biology &Drug Design, Volume 105, Issue 1, January 2025.
The future of treating challenging fungal infections lies in novel therapies targeting new antifungal targets, overcoming resistance mechanisms, and exploring innovative dual inhibitors. ABSTRACT Invasive fungal infections (IFIs) pose significant challenges in clinical settings, particularly due to their high morbidity and mortality rates.
Cengiz Zobi, Oztekin Algul
wiley   +1 more source

Brain Transcriptome Profiles of Greater Amberjack (Seriola dumerili) Juveniles Under Long‐Term Hypo‐ and Hypersaline Stress

Aquaculture Research, Volume 2025, Issue 1, 2025.
The fish brain plays a crucial role in regulating growth, reproduction, development, and adaptation to environmental stress. However, there are few studies that have examined the entire fish brain transcriptome and its responses to long‐term hypo‐ and hyper‐salinity stress. Greater amberjack (Seriola dumerili) has a high commercial value in mariculture
Xiaoying Ru, Yang Huang, Tong Zhou, Tonglin Yang, Peipei Chen, Jiahui Yang, Chunhua Zhu, Hongjuan Shi, Christyn Bailey   +8 more
wiley   +1 more source