Results 21 to 30 of about 2,059 (132)

Regulation of raft architecture [PDF]

, 2018
Summary: Raft membrane domains are envisioned as lateral assemblies of cholesterol and sphingolipids which adopt a liquid-ordered membrane phase. Our understanding of the raft architecture in cell membranes is developing rapidly.
Harder, T., Scheiffele, P.
core  

The disruption of GDP-fucose de novo biosynthesis suggests the presence of a novel fucose-containing glycoconjugate in Plasmodium asexual blood stages [PDF]

, 2016
Glycosylation is an important posttranslational protein modification in all eukaryotes. Besides glycosylphosphatidylinositol (GPI) anchors and N-glycosylation, O-fucosylation has been recently reported ...
A Cortes, AG Maier, AR Gomes, B Yilmaz, BS Crabb, C Aurrecoechea, CJ Woodrow, D Gowda, D Vasudevan, DC Gowda, DC Turnock, DJ Becker, EA Kimura, G Krishnegowda, GG Bushkin, H Ginsburg, I Matsumoto, J Le Pendu, J Rabina, J Samuelson, J Schindelin, J Thompson, JA Rodrigues, K Kirk, KE Swearingen, L Izquierdo, L Schofield, L Schwartz, M Cova, M von Itzstein, MB Doud, MJ Downie, MJ McConville, N Rovira-Graells, O Uchime, P Gerold, P Urbán, P Wang, PM Coutinho, PR Sanders, R Caputto, R Chattopadhyay, R Ramasamy, RJ Kelly, S Damerow, S Sanz, SE Lindner, T Naderer, TW Kooij, W Trager, Y Luo   +50 more
core   +2 more sources

Detection of Diagnostic Antibodies in Immune‐Mediated Diseases: A Focus on Antigens and Technologies

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review explores autoantibody detection in immune‐mediated diseases, highlighting autoantigens including post‐translational modifications. We compared enzyme‐linked immunosorbent assay and indirect immunofluorescence with automated chemiluminescence platforms.
Silvia Bracci, Feliciana Real‐Fernandez, Federico Pratesi, Francesca Nuti, Paolo Rovero, Anna Maria Papini   +5 more
wiley   +1 more source

Drug Delivery of Oligonucleotides at the Blood-Brain Barrier: a Therapeutic Strategy for Inflammatory Diseases of the Central Nervous System [PDF]

, 2003
In this project a vector for drug delivery into brain endothelial cells, consisting of an anti-transferrin receptor antibody and a complex of polyethylenimine (PEI) and an oligodeoxynucleotide (ODN) drug was evaluated.
Osburg, Berit, Voigt, Karlheinz Prof. Dr. med.   +1 more
core   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, Volume 13, Issue 18, 27 March 2026.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

PP2A/B56 and GSK3/Ras suppress PKB activity during Dictyostelium chemotaxis [PDF]

, 2015
We have previously shown that the Dictyostelium protein phosphatase 2A regulatory subunit B56, encoded by psrA, modulates Dictyostelium cell differentiation through negatively affecting glycogen synthase kinase 3 (GSK3) function.
Castillo, Boris, Kim, Bohye, Kim, Lou W., Rodriguez Pino, Marbelys   +3 more
core   +1 more source

Probiotic Lactobacillus plantarum NCU001563 Alleviates Ulcerative Colitis via Immunomodulation, Microbiota Remodeling, and Production of Armillarivin and Caffeoyl Aspartic Acid

Food Frontiers, Volume 7, Issue 2, March 2026.
A graphical representation of how Lactobacillus plantarum NCU001563 alleviates ulcerative colitis. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) driven by microbial dysbiosis, barrier dysfunction, and immune dysregulation.
Philippe Madjirebaye, Naeem Ullah, Muhammad Mazhar, Abdul Mueed, Zhen Peng, Muhammad Abaidullah, Yun Liao, Yuting Fan, Ping Tang, Jing Li, Tao Xiong, Pingchang Yang, Xuli Wu   +12 more
wiley   +1 more source

Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Targeted protein degradation based on LYTAC technology has recently emerged as a research hotspot in various diseases. The membrane receptors recently utilized in LYTAC design are summarized in this article, with insights into current strategies, challenges, and prospects for LYTAC‐based technologies.
Lijian Shen, Ziyi Liang, Ying Zhang, Jing Wen, Jie Gao   +4 more
wiley   +1 more source

Targeted treatment of folate receptor-positive platinum-resistant ovarian cancer and companion diagnostics, with specific focus on vintafolide and etarfolatide [PDF]

, 2014
Among the gynecological malignancies, ovarian cancer is the leading cause of mortality in developed countries. Treatment of ovarian cancer is based on surgery integrated with chemotherapy.
Canaparo, Roberto, Dosio, Franco, Gallicchio, Margherita, Serpe, Loredana   +3 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source