Results 11 to 20 of about 2,059 (132)

Microdomains of GPI-anchored proteins in living cells revealed by crosslinking [PDF]

Nature, 1998
There is some discussion as to whether glycosyl-phosphatidylinositol(GPI)-anchored proteins occur in microdomains in the cell membrane. These putative microdomains have been implicated in processes such as sorting in polarized cells and signal ...
Friedrichson, T., Kurzchalia, T.V.
core   +3 more sources

The Role of the CLIC/GEEC Endocytic Pathway for Mechanophysical Transfection of DNA. [PDF]

J Gene Med
The clathrin‐independent carriers/GPI‐enriched endocytic compartments (CLIC/GEEC or CG) pathway is a high‐capacity, clathrin‐, and dynamin‐independent route for nutrient and membrane‐anchored cargo uptake of DNA. This overview highlights its molecular mechanisms, regulation, cellular roles, and relevance to mechanophysical DNA transfection.
Weaver S, Lallow EO, Kyker-Snowman K, Jhumur NC, Gulley M, Roberts CC, Shreiber DI, Lin H, Maslow JN.   +8 more
europepmc   +2 more sources

Fundamental Neurochemistry Review: Sphingolipids and Ceramides in Brain Development. [PDF]

J Neurochem
Ceramides and sphingolipids in brain development and cell compartments. Ceramides and sphingolipids are known to influence multiple steps of brain development, including the formation of the neural tube, neural stem cell polarity and proliferation at the ventricular boundary, neuronal migration—for example, whilst migrating on radial glial processes ...
Chinnappa K, Ballorin F, Francis F.
europepmc   +2 more sources

Targeted Fluoromagnetic Nanoparticles for Imaging of Breast Cancer MCF-7 Cells [PDF]

, 2013
Purpose: To achieve simultaneous imaging and therapy potentials, targeted fluoromagnetic nanoparticles were synthesized and examined in human breast cancer MCF-7 cells.
Davoud Asgari, Hadi Valizadeh, Jaleh Barar, Javid Shahbazi, Mohammad Reza Rashidi, Mostafa Heidari Majd, Vala Kafil, Yadollah Omidi   +7 more
core   +1 more source

Neural tube closure: cellular, molecular and biomechanical mechanisms. [PDF]

, 2017
Neural tube closure has been studied for many decades, across a range of vertebrates, as a paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the severe congenital malformations - 'neural tube defects' - that result ...
Copp, AJ, Galea, GL, Greene, ND, Nikolopoulou, E, Rolo, A   +4 more
core   +2 more sources

Secretory pathway of trypanosomatid parasites [PDF]

, 2002
The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause important diseases in humans. These include Tryanosoma brucei (the causative agent of African sleeping sickness and nagana in cattle), Trypanosoma cruzi (the causative
McConville, Malcolm J., Mullin, Kylie A., Ilgoutz, Steven C., Teasdale, Rohan D.   +3 more
core   +1 more source

Folate-targeted nanoparticles for rheumatoid arthritis therapy [PDF]

, 2016
Rheumatoid arthritis (RA) is the most common inflammatory rheumatic disease, affecting almost 1% of the world population. Although the cause of RA remains unknown, the complex interaction between immune mediators (cytokines and effector cells) is ...
Cavaco-Paulo, Artur, Gomes, Andreia C., Nogueira, Eugénia Sofia Costa, Preto, Ana   +3 more
core   +1 more source

Glycosyl Mobile Radical Structures of Folic Acid Receptors Impact the Internalization of Functionalized Folate Amphiphilic Alternating Copolymer in Cancer Cells

Receptors
Folate receptor alpha (FRα) is a glycosylphosphatidylinositol (GPI) membrane-anchored protein containing three N-glycosylated residues at the N47, N139, and N179 termini.
Emilyn B. Aucoin, Elizabeth Skapinker, Abdulrahman M. Yaish, Yunfan Li, Haley L. Kombargi, Daniel Jeyaraj, Pankaj Garg, Nicole Mendonza, Cecile Malardier-Jugroot, Myron R. Szewczuk   +9 more
doaj   +1 more source

Breed and adaptive response modulate bovine peripheral blood cells’ transcriptome [PDF]

, 2015
Background: Adaptive response includes a variety of physiological modifications to face changes in external or internal conditions and adapt to a new situation.
SA Kinlein, MN Silverman, HA Selye, IJ Elenkov, PD Eckersall, SM Haeryfar, J Kent, JG Conner, A Horadagoda, A Dowling, SP Alsemgeest, P Jawor, M Amadori, C Cray, S Ranabir, S Hing, G Solano-Aguilar, KE McLoughlin, H Shin, R Weikard, A O’Loughlin, V Chai, ER Mardis, Z Wang, S Wickramasinghe, Y Han, M Bionaz, Institut National de la Recherche Agronomique, S Sgorlon, S Sgorlon, A Schroeder, S Sgorlon, GC Elsik, MI Love, Y Benjamini, DW Huang, A Sundrum, A Papadimitriou, JC Buckingham, T Kitajima, GP Chrousos, RS Weinstein, M Doga, Y Tamura, O Schakman, C Tsigos, P Anagnostis, AJ Rose, P Joseph-Bravo, NC Nicolaides, M Kaneisha, MC Hanna, MD Toney, NB Livanova, C Beedham, TK Kundu, J Sahi, E Garattini, H Li, JO Lundberg, M Izumi, P Hänzelmann, BI Labow, T Wen, T Ohto, JE Burke, T Schulz-Utermoehl, KC Patki, N Hanioka, R Harrison, A Ives, SJ Chung, OH Temmink, AB Kuilenburg Van, D Boraschi, K Oshimi, N Burdin, F Biet, Y Mukai, SG Pereira, ML Ponce, K Dib, JM Cook-Mills, J Sottile, KC DeHahn, A Kawakami, S Viriyakosol, I Sabroe, MA Hadders, Y Qiu, S Koyasu, AE Ting, S Christensen, AK Ekman, A Dufner, R Zhou, M Proell, LC Wang, J Dwyer, A Siritantikorn, SA Marchitti, AE Medvedev, Y Chen, N Heisterkamp, DO Morgan, JR Ingelfinger, ME Selsted, EM Kościuczuk, A Janowska-Wieczorek, B Vafadari, W Schrödl   +110 more
core   +1 more source

Diverse viral glycoproteins as well as CD4 co-package into the same human immunodeficiency virus (HIV-1) particles [PDF]

, 2014
BACKGROUND: Retroviruses can acquire not only their own glycoproteins as they bud from the cellular membrane, but also some cellular and foreign viral glycoproteins.
Devon A Gregory, Grace Y Olinger, Marc C Johnson, Tiffany M Lucas   +3 more
core   +2 more sources