Results 181 to 190 of about 6,879 (261)

A Systematic Review of Folate and the Human Enteric Microbiome: Biological Mechanisms and Clinical Implications. [PDF]

Int J Mol Sci
Khanduja R, Frye RE.
europepmc   +1 more source

An eye on long‐duration spaceflight: Controversies, countermeasures and challenges

Experimental Physiology, EarlyView.
Abstract Space flight‐associated neuroocular syndrome (SANS) is a consequence of long‐duration space flight and is detected in two‐thirds of astronauts. In‐flight, this can cause a change in the refraction of the eyes, requiring graded hypermetropic ‘superfocus adjustable’ glasses, optic nerve head oedema and choroidal folds.
Vincent Wing Sum Ng, Susan Patricia Mollan   +1 more
wiley   +1 more source

Glucarpidase efficacy in mitigating methotrexate toxicity is unaffected by concurrent administration of folinic acid. [PDF]

Cancer Chemother Pharmacol
Wahlestedt M, Hansson K, Bill A, Isaksson A, Heldrup J, Pronk CJ.   +5 more
europepmc   +1 more source

Expression characteristics of dual‐specificity phosphatase 2 and hypoxia‐inducible factor‐1α in acute kidney injury and preliminary study of the effect of dual‐specificity phosphatase 2 on HK‐2 cells

Experimental Physiology, EarlyView.
ABSTRACT Acute kidney injury (AKI) is a global health problem with significant long‐term harm if the prognosis is poor. Dual‐specificity phosphatase 2 (DUSP2) is involved in key regulatory pathways in several disease processes, but its function in renal pathophysiology is unclear.
Xueqian Chu, Songmin Xue, Lanyan Lin, Xuan Huang, Sisi Chen, Wulaer Adeli, Zulibiya Tuohetiyaer, Suhua Li, Chen Lu   +8 more
wiley   +1 more source

Mitochondria protect against an intracellular pathogen by restricting access to folate. [PDF]

Science
Medeiros TC, Ovciarikova J, Li X, Krueger P, Bartsch T, Reato S, Crow JC, Tellez Sutterlin M, Martins Garcia B, Rais I, Allmeroth K, Hartman MD, Denzel MS, Purrio M, Mesaros A, Leung KY, Greene NDE, Sheiner L, Giavalisco P, Pernas L.   +19 more
europepmc   +1 more source

Intermittent hand and forearm immersion in 20°C water attenuates thermal, cardiovascular, and perceptual strain in older adults during heat stress

Experimental Physiology, EarlyView.
Abstract Adults >65 years of age experience deleterious health effects during extreme heat events at a greater rate than any other age cohort. The purpose of this study was to identify the effectiveness of acute intermittent hand and forearm (H+F) water immersion and/or chronic (7 week) folic acid supplementation on reducing thermal and cardiovascular ...
Rachel M. Cottle, Kat G. Fisher, Olivia K. Leach, David E. Conroy, Lacy M. Alexander, W. Larry Kenney   +5 more
wiley   +1 more source

Effect of Sertraline on Fetoplacental Growth Parameters and Placental Transporter Gene Expression in Rats. [PDF]

Int J Mol Sci
Enriquez-Mendiola D, Sifuentes-García JE, Barragán-Zúñiga LJ, Vértiz-Hernández AA, Lazalde-Ramos BP, Damiano AE, Galaviz-Hernández C, Sosa-Macías M.   +7 more
europepmc   +1 more source

Glucocorticoids modulate drug transporter function in human fetal brain endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend P‐glycoprotein and breast cancer resistance protein are the most prominent drug transporters at the fetal blood–brain barrier. We isolated primary human fetal brain endothelial cells from early and mid‐gestation cerebral microvessels and exposed them to glucocorticoids cortisol and dexamethasone in vitro.
Nikola Ivanovski, Phetcharawan Lye, Enrrico Bloise, Stephen G. Matthews   +3 more
wiley   +1 more source

Folate depletion impact on the cell cycle results in restricted primary root growth in Arabidopsis. [PDF]

Plant Mol Biol
De Lepeleire J, Mishra RC, Verstraete J, Pedroza Garcia JA, Stove C, De Veylder L, Van Der Straeten D.   +6 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source