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Autoantibodies to Folate Receptors in the Cerebral Folate Deficiency Syndrome
New England Journal of Medicine, 2005In infantile-onset cerebral folate deficiency, 5-methyltetrahydrofolate (5MTHF) levels in the cerebrospinal fluid are low, but folate levels in the serum and erythrocytes are normal. We examined serum specimens from 28 children with cerebral folate deficiency, 5 of their mothers, 28 age-matched control subjects, and 41 patients with an unrelated ...
Ramaekers, Vincent +6 more
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Conformational analysis of folates and folate analogues
International Journal of Quantum Chemistry, 2009Conformational energy calculations have been performed on a series of folates and folate analogues, including dihydrofolate and methotrexate. A large number of conformations are energetically accessible to these molecules, and some are common to all. The conformations adopted by methotrexate, when bound to dihydrofolate reductases from various sources,
M. J. Spark +2 more
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Journal of Clinical Pathology, 2011
The measurement of total folate in clinical material became possible with the introduction of the Lactobacillus casei assay some 50 years ago. The use of lactoglobulin as a folate binding agent to measure folate by radioisotope dilution, later fluorimetry, is more user friendly but gives largely similar results. The principal folate …
openaire +2 more sources
The measurement of total folate in clinical material became possible with the introduction of the Lactobacillus casei assay some 50 years ago. The use of lactoglobulin as a folate binding agent to measure folate by radioisotope dilution, later fluorimetry, is more user friendly but gives largely similar results. The principal folate …
openaire +2 more sources
Role of Folate Binding Proteins in Folate Metabolism
1990The essential role of folates in cellular biochemistry is well established, but the nature of the participation by folate-binding proteins has been disputed. This review will define folate-binding proteins and distinguish them from low-affinity, nonspecific folate binders and folate-dependent intracellular enzymes.
M A, Kane, S, Waxman
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Emerging roles for folate receptor FOLR1 in signaling and cancer
Trends in Endocrinology and Metabolism, 2022Edward T Kipreos
exaly