Results 41 to 50 of about 152,541 (294)
Implantation of atelocollagen sheet for vocal fold scar [PDF]
Current Opinion in Otolaryngology & Head & Neck Surgery, 2010 This article reviews recent advances in scaffold-based interventions for the treatment of vocal fold scarring, with a particular emphasis on atelocollagen sheet implantation in the vocal fold lamina propria.Scaffold-based therapies have demonstrated therapeutic promise in both preclinical and early clinical studies.
Yo, Kishimoto +2 more
openaire +2 more sources
Toxins, 2019 Native disulfide formation is crucial to the process of disulfide-rich protein folding in vitro. As such, analysis of the disulfide bonds can be used to track the process of the folding reaction; however, the diverse structural isomers interfere with ...
Sheng-Yu Huang +6 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Folding Large Antenna Tape Spring [PDF]
, 2008 This paper presents a novel concept for a low-mass, 50-m^2-deployable, P-band dual polarization antenna that can measure terrestrial biomass levels from a spacecraft in a low Earth orbit.
Howard, P. +3 more
core +2 more sources
Geometry-Driven Folding of a Floating Annular Sheet
Physical Review Letters, 2017 Predicting the large-amplitude deformations of thin elastic sheets is difficult due to the complications of self-contact, geometric nonlinearities, and a multitude of low-lying energy states. We study a simple two-dimensional setting where an annular polymer sheet floating on an air-water interface is subjected to different tensions on the inner and ...
Paulsen, Joseph +6 more
openaire +5 more sources
A pH Switch for β‐Sheet Protein Folding [PDF]
Angewandte Chemie, 2017 AbstractProtein design advancements have led to biotechnological strategies based on more stable and more specific structures. Herein we present a 6‐residue sequence (HPATGK) that acts as a stable structure‐nucleating turn at physiological and higher pH but is notably unfavorable for chain direction reversal at low pH.
Jordan M. Anderson, Niels H. Andersen
openaire +2 more sources
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Topological Solitons and Folded Proteins [PDF]
, 2010 We propose that protein loops can be interpreted as topological domain-wall solitons. They interpolate between ground states that are the secondary structures like alpha-helices and beta-strands.
Antti J. Niemi +6 more
core +5 more sources
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman +9 more
wiley +1 more source