Results 221 to 230 of about 10,115,388 (315)

Backbone double-mutant cycle analysis quantifies hydrogen-bond energies in proteins. [PDF]

Protein Sci
Zheng H, Newberry RW.
europepmc   +1 more source

Some considerations about fold models

The Journal of the Geological Society of Japan, 1973
openaire   +2 more sources

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Benchmarking antigen-aware inverse folding methods for antibody design. [PDF]

Bioinform Adv
Janusz B, Chomicz D, Wrobel S, Dudzic P, Polasa A, Martin K, Darnell S, Comeau SR, Krawczyk K.   +8 more
europepmc   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Sequence-Encoded Frustration Directs the Formation of Abridged G-Quadruplex Architectures. [PDF]

Angew Chem Int Ed Engl
Qian Y, Ali MY, Karsisiotis AI, Dillon P, Dvorkin SA, McPherson PAC, Webba da Silva M.   +6 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pseudouridine synthase PUS1 and initiation factor mtIF2 are human mitoribosomal small subunit assembly factors. [PDF]

Nat Commun
Singh V, Shiriaev D, Bilalli L, Khawaja A, Rorbach J.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Optimization and evaluation of gastro-expandable film of Eudragit S100 and ethylcellulose by using the design of experiment. [PDF]

Sci Rep
Dass R, Rani P, Verma V, Kumar D, Bhatia M, Kondaveeti SB.   +5 more
europepmc   +1 more source