Dynamics in unfolded polypeptide chains as model for elementary steps in protein folding [PDF]
, 2004 This thesis deals with the dynamics of unfolded polypeptide chains as model for the earliest steps in protein folding. Starting from an ensemble of unfolded conformations a folding polypeptide chain has to form specific backbone and side-chain ...
Krieger, Florian
core +1 more source
Folding-Assisted Peptide Disulfide Formation and Dimerization [PDF]
, 2023 Disulfide bonds form covalent bonds between distal regions of peptides and proteins to dramatically impact their folding, stability, and oligomerization.
Clara G. Victorio (16475762) +3 more
core +1 more source
Prediction of optimal folding routes of proteins that satisfy the principle of lowest entropy loss: dynamic contact maps and optimal control. [PDF]
PLoS ONE, 2010 An optimization model is introduced in which proteins try to evade high energy regions of the folding landscape, and prefer low entropy loss routes during folding.
Yaman Arkun, Burak Erman
doaj +1 more source
The “Beacon” Structural Model of Protein Folding: Application for Trp-Cage in Water
Molecules, 2023 Protein folding is a process in which a polypeptide must undergo folding process to obtain its three-dimensional structure. Thermodynamically, it is a process of enthalpy to overcome the loss of conformational entropy in folding.
Qiang Sun, Xian He, Yanfang Fu
doaj +1 more source
Without magic bullets: the biological basis for public health interventions against protein folding disorders [PDF]
, 2010 Protein folding disorders of aging like Alzheimer's and Parkinson's diseases currently present intractable medical challenges. 'Small molecule' interventions - drug treatments - often have, at best, palliative impact, failing to alter
Rodrick Wallace
core +2 more sources
Protein folding disorders: Toward a basic biological paradigm [PDF]
, 2010 Mechanistic 'physics' models of protein folding fail to account for the observed spectrum of protein folding and aggregation disorders, suggesting that a more appropriately biological paradigm will be needed for understanding the etiology ...
Rodrick Wallace
core +2 more sources
14C(11B, 9Be)16N reaction mechanisms and potential of the 9Be + 16N interaction [PDF]
Ядерна фізика та енергетика, 2013 New experimental data for differential cross sections of the 14С(11B, 9Be)16N reaction were measured for the ground states of 9Be and 16N nuclei as well as for the excited states of 16N at the energy Elab.(11В) = 45 MeV.
S. Yu. Mezhevych +11 more
doaj
Protein Folding and Macromolecular Dynamics: Fundamental Limits of Length and Time Scales [PDF]
, 2012 In this thesis, physics-based models of protein folding at the secondary and tertiary level are developed to resolve long-standing issues of protein folding kinetics.
Lin, Milo Miaoyu
core +1 more source
Isotopic effects in elastic and inelastic 12,13C + 16,18O scattering [PDF]
Ядерна фізика та енергетика, 2010 New angular-distribution data of 13С + 18О elastic and inelastic scattering at the energy Elab(18O) = 105 MeV were obtained for the transitions to the ground and excited states 3.088 MeV(1/2+), 3.555 MeV (1/2-), 3.854 MeV (5/2+) of 13С and 1.982 MeV (2+
A. T. Rudchik +17 more
doaj
Proteome folding kinetics is limited by protein halflife. [PDF]
PLoS ONE, 2014 How heterogeneous are proteome folding timescales and what physical principles, if any, dictate its limits? We answer this by predicting copy number weighted folding speed distribution - using the native topology - for E.coli and Yeast proteome.
Taisong Zou +3 more
doaj +1 more source