Results 41 to 50 of about 232,357 (217)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
AIP AdvancesFor meeting the requirements of tactical missiles seeking miniaturized launch devices for storage, transportation, and launch, a tube-launched missile wing is adopted, which folds before launch and quickly unfolds after launch.
Tiegang Lv +7 more
doaj +1 more source
Aerodynamic Analysis and Simulation for a Z-Shaped Folding Wing UAV
AerospaceThe potential of folding wing unmanned aerial vehicles (UAVs) in enhancing the adaptability of complex missions is substantial. Analyzing the aerodynamic characteristics of these UAVs is vital for optimizing the design of their folding wing configuration
Jin-Gang Wang, Xiang-Ying Guo
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Tissue-scale in vitro epithelial wrinkling and wrinkle-to-fold transition
Nature CommunicationsAlthough epithelial folding is commonly studied using in vivo animal models, such models exhibit critical limitations in terms of real-time observation and independent control of experimental parameters.
Jaeseung Youn +4 more
doaj +1 more source
Engineered ScienceDuring the working process of the folding wing, there is not only a large-range rigid body motion but also a deformation motion of the flexible components. The problem of the rigid-flexible coupling of the structure is extremely complex.
Xinqiang Lu, Rui Yang, Shiyong Sun
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Magnetic tweezers to capture the fast-folding λ6-85 in slow motion
Communications PhysicsForce spectroscopy gives access to the underlying free energy landscape of protein folding. Proteins exhibit folding rates between microseconds and hours.
César Augusto Quintana-Cataño +5 more
doaj +1 more source