Results 141 to 150 of about 199,379 (359)

Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes

open access: yesChemBioChem, EarlyView.
In the nascent processes of the beginnings and evolution of life, nucleobases and especially purines, ribonucleos(t)ides and primitive RNAs have been continuously modified. A RNA‐peptide world and key metabolic pathways probably have emerged from the corresponding chemical modifications resulting from adenine deamination, purine alkylation and ...
Jean‐Luc Décout   +1 more
wiley   +1 more source

Synthesis Strategies and Electrochemical Research Progress of Nano/Microscale Metal–Organic Frameworks

open access: yesSmall Science, Volume 2, Issue 12, December 2022., 2022
Nano/microscale metal–organic frameworks (MOFs) with controllable size and shape can be synthesized by various strategies, which possess unique properties compared with bulk MOFs and show great potential in energy storage and conversion fields. Nanoscale/microscale metal–organic frameworks (nano/microscale MOFs) are considered kinds of nanomaterials ...
Shixian Wang   +6 more
wiley   +1 more source

Assessment of folic acid and DNA damage in cleft lip and cleft palate

open access: yesClinics and Practice, 2014
Studies have identified the risk factors like folic acid deficiency during gestational period, family history for orofacial clefts, drugs like antiepileptic, vitamin A.
Sivakumar Brooklyin   +4 more
doaj   +1 more source

The Protective Role of Folic Acid and Vitamin E Against Toxical Effects of Valproic Acid on Liver Tissue During Period of Gestation [PDF]

open access: yes, 2004
Valproic acid is an anticonvulsan drug used in epilepsy. Thehistopathological changes of valproic acid on liver and the protective effectof vitamin E and also folic acid were observed. 24 adult female Wistar Albinorats were used.
Ayşe Yıldırım   +2 more
core  

PCFT Independent Cellular Uptake of Cyclic Cell Penetrating Peptide Conjugated Folic Acid

open access: yesChemBioChem, Accepted Article.
Folic acid is an essential component of many metabolic processes, including the synthesis of nucleoproteins, purines, and pyrimidines and is a recommended supplement to lower the incidence of various disorders. Folic acid and folate loaded nanoparticles are extensively evaluated for sustained release and enhanced stability of the molecule, however ...
Vineet Kumar Mishra   +3 more
wiley   +1 more source

LC/ESI-MS analysis of underivatized amino acids and mass spectrum [PDF]

open access: yesarXiv, 2016
We report the method of LC/ESI-MS analysis of underivatized amino acids with corresponding mass spectrum and fragmentation patterns. Diagnostic product ions determined by mass spectrometry can support the qualitative identification and quantitative estimation of individual amino acids. Therefore, the optimization of chromatographic separation using the
arxiv  

Correlations of Amino Acids with Secondary Structure Types: Connection with Amino Acid Structure [PDF]

open access: yesarXiv, 2005
The correlations of primary and secondary structures were analyzed using proteins with known structure from Protein Data Bank. The correlation values of amino acid type and the eight secondary structure types at distant position were calculated for distances between -25 and 25.
arxiv  

Quantitative Investigation of Nitrosamine Drug Substance‐Related Impurities (NDSRIs) Under Artificial Gastric Conditions by Liquid Chromatography–Tandem Mass Spectrometry and Structure–Activity Relationship Analysis

open access: yesDrug Testing and Analysis, EarlyView.
The study provides information about the impact of physiological gastric conditions on the unbeneficial occurrence of nitrosamine drug substance–related impurities (NDSRIs). Both main factors for nitrosation in the form of acidic conditions and the presence of nitrite were adequately chosen for triggering the conversion of drug compounds into NDSRIs ...
Matthias Vogel   +5 more
wiley   +1 more source

The primary prevention of birth defects: Multivitamins or folic acid?

open access: yesInternational Journal of Medical Sciences, 2004
Periconceptional use of folic acid alone or in multivitamin supplements is effective for the primary prevention of neural-tube defects. The Hungarian randomized and two-cohort controlled trials showed that periconceptional multivitamin supplementation ...
doaj  

Home - About - Disclaimer - Privacy