Results 231 to 240 of about 8,616,641 (354)

Reduced Circulating Regulatory T Cells in Autoimmune and Chronic Idiopathic Neutropenia of Childhood: An Observational Study of Clinical and Laboratory Associations

open access: yesEuropean Journal of Haematology, EarlyView.
ABSTRACT Objectives To investigate circulating regulatory T cells (Tregs) in children with autoimmune neutropenia (AIN) and chronic idiopathic neutropenia (CIN) and evaluate their associations with clinical and laboratory features of neutropenia. Methods Plasma and Peripheral Blood Mononuclear Cells (PBMCs) were collected from 69 participants.
Konstantina Toutoudaki   +12 more
wiley   +1 more source

Blocking protein quality control degradation leads to structural stabilization of DHFR indel variants

open access: yesThe FEBS Journal, EarlyView.
Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet   +6 more
wiley   +1 more source

Using 6S-5-methyltetrahydrofolate instead of folic acid in prenatal multivitamin reduces unmetabolized folic acid concentrations in the mother-fetus dyad: a 24-week randomized controlled trial. [PDF]

open access: yesFront Nutr
Draicchio F   +11 more
europepmc   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

open access: yesThe FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Preparing for pregnancy while living with HIV: An exploratory qualitative study of Women's preconception information needs and priorities

open access: yesHIV Medicine, EarlyView.
Abstract Introduction Preconception health is a key determinant of birthing people and infant outcomes. However, for people living with HIV, preconception care has predominantly focused on preventing vertical transmission, often neglecting broader needs.
Catherine Stewart   +5 more
wiley   +1 more source

Fluoride‐Free Mouthwashes Available Over‐The‐Counter in the US‐An Overview

open access: yesInternational Journal of Dental Hygiene, EarlyView.
ABSTRACT Purpose Fluoride‐free mouthwashes (FFM) are commonly used by patients for a variety of cosmetic and/or therapeutic reasons. The purpose of this study was to investigate the composition and purposes of FFM available over‐the‐counter in the US.
Astrid C. Valdivia‐Tapia   +3 more
wiley   +1 more source

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