Results 111 to 120 of about 2,739,853 (293)
Synergistic Antimicrobial Activities of Folic Acid Antagonists and Nucleoside Analogs
, 2009 The antimicrobial activities of folic acid antagonists are supposed to be antagonized by elevated extracellular thymidine concentrations in damaged host tissues.
Johannes Z +3 more
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British Journal of Pharmacology, EarlyView.Extracellular vesicles (EVs) are a diverse population of membrane nanoparticles secreted by nearly all cell types, playing a key role in intercellular communication by transferring bioactive macromolecular cargo. In cancer, EVs shape both the local tumour microenvironment and distant premetastatic niches.
Evangelia Pantazaka +3 more
wiley +1 more source
Serum Folic Acid Predicted Pre-Operative Aortic Rupture in Symptomatic Aortic Aneurysm Dissection: A Prospective, Single-Center, Observational Study [PDF]
Feier Song,1,* Zhengbo Chen,2,* Zhibo Yang,3,* Guoxiang Zou,3 Baojuan Liu,1 Weifeng Li,3 Yimei Hong,1 Jinxiu Meng,4 Gang Zhao,2 Abdelouahab Bellou,5 Xin Li3 1Department of Emergency Medicine and Emergency Intensive Care Unit ...
Li W +10 more
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Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background This trial aimed to evaluate the efficacy of oral acetazolamide in reducing cystoid fluid collections (CFC) and improving visual function in patients with X‐linked retinoschisis (XLRS). Methods In this investigator‐initiated, single centre, open‐label, randomised controlled trial, XLRS patients aged ≥ 12 years with fovea‐involving ...
Jonathan Hensman +15 more
wiley +1 more source
The FEBS Journal, EarlyView.Blocking protein quality control degradation by deleting the E3 ligases Ubr1 or San1 stabilizes many DHFR insertion and deletion variants that are otherwise partially unfolded. These hypomorphic variants regain folding at lower temperatures or upon methotrexate binding, revealing that PQC degradation can remove proteins that are still functionally ...
Sven Larsen‐Ledet +6 more
wiley +1 more source
Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance
The FEBS Journal, EarlyView.Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley +1 more source
Folic Acid-Targeted Liposome-Based Nanoparticle Loaded with Sorafenib for Liver Cancer Therapy [PDF]
Songyang Liu,1 Dan Yi,1,2 Rui Ma,1 Wei Zhang1 1Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130061, People’s Republic of China; 2Department of VascularSurgery Qiqihar first
Zhang W, Ma R, Liu S, Yi D
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Risk Factors and Management of Gingival Enlargement: A Systematic Review and Meta‐Analysis
Journal of Clinical Periodontology, EarlyView.ABSTRACT Objective To identify risk factors/indicators of gingival enlargement (GE) and to summarise evidence for its management. Methods A systematic review was undertaken following PRISMA guidelines and divided into PECOTS and PICOTS questions, related to risk factors/indicators and treatment studies, respectively.
Luigi Nibali +5 more
wiley +1 more source
Close relationship between β2‐microglobulin and type 2 diabetes‐associated peripheral neuropathy
Journal of Diabetes Investigation, EarlyView.ABSTRACT Aims/Introduction This study aimed to elucidate the correlation between β2‐microglobulin (β2‐MG) and peripheral neuropathy in type 2 diabetes mellitus (T2DM). Materials and Methods Diabetic peripheral neuropathy (DPN) was defined on the nerve conduction study (NCS).
Jingfang Shao +3 more
wiley +1 more source