Results 181 to 190 of about 2,739,853 (293)

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1989-1999, September 2026.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Antifolate agent aminopterin demonstrates potent anti-monkeypox virus activity <i>in vitro</i> and <i>in vivo</i>. [PDF]

Microbiol Spectr
Wu J, Duan M, Cheng L, Chen D.
europepmc   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source

Impact of RAASIs on Potassium and Mortality in a Large Cohort of Hemodialysis Patients: Practical Excursus and Comparison Between Traditional Statistics and Machine Learning. [PDF]

J Clin Med
Calabrese V, Stancanelli MR, Sberna ME, Taverna G, Geraci G, Cernaro V, Santoro D.   +6 more
europepmc   +1 more source

The mode of action of folic acid antagonists on cells

The Journal of Physiology, 1954
openaire   +3 more sources

Reactive Oxygen Species in Breast Cancer: From Redox Dysregulation to ROS‐Responsive Therapeutics

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer is the most frequently diagnosed malignancy among women worldwide, with 2.3 million new cases and approximately 670,000 deaths reported in 2022 alone. Despite advances in therapy, metastasis and acquired drug resistance remain major clinical challenges.
Marija Nikolovska, Radoslav Stojchevski, Aleksandar Eftimov, Mitko Mladenov, Dimiter Avtanski, Nikola Hadzi‐Petrushev   +5 more
wiley   +1 more source

Ironing Out Possible Micronutrient Deficiencies Associated with Incretin Receptor Agonist-Based Therapies: Proposed Practical Strategies to Prevent and Manage Iron Deficiency. [PDF]

Nutrients
Infante M, Ricordi C, Pacifici F, Pastore D, Infante R, Caprio M, Chiereghin F, De Stefano A, Frank G, De Rose A, Romano L, Di Renzo L, Rovella V, De Lorenzo A, Donadel G, Della-Morte D.   +15 more
europepmc   +1 more source

Insights Into Aggregation‐Delayed Phenotype of Dictyostelium discoideum

Cell Biology International, Volume 50, Issue 9, September 2026.
ABSTRACT Dictyostelium discoideum is a cellular model that has been widely used in cell signal research focusing on different cellular and developmental processes. The unique lifecycle of these cells—which involves switching between vegetative and development phases—makes Dictyostelium a reliable model for investigations in this field.
Sarah Abdulaziz Alamer
wiley   +1 more source

The Metabolic Architecture of Glaucoma: A Unified Framework of Cofactor Failure and Kynurenine Dysregulation. [PDF]

Int J Mol Sci
Caikovska L, Veitners A, Lavrinovica D, Vanags J, Klavins K, Laganovska G, Zemitis A.   +6 more
europepmc   +1 more source

Possible Paraneoplastic Amyotrophic Lateral Sclerosis Presenting as Respiratory Failure in a Breast Cancer Patient: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
In a breast cancer patient with acute hypercapnic respiratory failure, paraneoplastic ALS was diagnosed despite negative onconeural antibodies. Red flags included diaphragmatic paralysis, ESR of 120 mm/h, and CSF protein of 246 mg/dL. Clinicians should consider this diagnosis even when antibody panels are negative.
Maryam Albaji, Khashayar Ashkboos, Kosar Bagherzadeh   +2 more
wiley   +1 more source