Results 241 to 250 of about 2,739,853 (293)

FOLIC ACID ANTAGONISTS IN THE TREATMENT OF ACUTE AND SUBACUTE LEUKEMIA

Blood, 1950
William Dameshek, Milton H. Freedman, Lester A. Steinberg   +2 more
exaly   +2 more sources

A method for the quantitative comparison of anticancer agents with special reference to a series of folic acid antagonists.

Journal of Pharmacology and Experimental Therapeutics, 1960
A method is outlined for the quantitative comparison of active antitumor compounds. This method has been applied to studies with the 6C3HED Iymphosarcoma in C 3 H mice.
A. Sloboda
semanticscholar   +1 more source

Folic Acid, its Analogs and Antagonists

1960
Publisher Summary Folic acid has many functions in the body, and when it is lacking, anemia is only part of a generalized disorder that undermines the health of the sufferer. After a brief historical review, this chapter deals with the metabolic functions of folic acid. The actions of folic acid antagonists are considered and attention is directed to
openaire   +2 more sources

Inhibition of the Neutrophil Nrdph Oxidase by Folic Acid and Antagonists of the Folic Acid Metabolism

Immunopharmacology and Immunotoxicology, 1992
The influence of folic acid and several antagonists of the folic acid metabolism on neutrophil superoxide generation was investigated with the cytochrome c reduction assay. The compounds were found to be partial competitive inhibitors of the NADPH oxidase, their activity apparently increasing with larger substituents at the 10 position.
G F, Weber, M G, Nair
openaire   +2 more sources

Scurvy Following Folic Acid Antagonist Therapy

Radiology, 1956
Although folic acid antagonists have been widely used in recent years, there have been only a few reports of their effects on Vitamin C metabolism. Recently, we have seen a patient with widespread neuroblastoma in whom typical scorbutic changes developed in the long bones during the course of aminopterin therapy. Case Report B. P., a 16-month-old white
J M, DENNIS, R, MERCADO
openaire   +2 more sources

Parenteral vs. Oral Folic Acid Antagonists

Archives of Dermatology, 1964
Parenteral methotrexate is an effective medication for controlling severe psoriasis. The necessary clinical and laboratory precautions discussed above must be carefully followed. Parenteral methotrexate was successful in patients in whom oral aminopterin or oral methotrexate did not clear the psoriatic lesion.
openaire   +2 more sources

In Silico Structure Based Designing of Dihydrofolate Reductase Enzyme Antagonists and Potential Small Molecules That Target DHFR Protein to Inhibit the Folic Acid Biosynthetic Pathways

International Conference on Computational Systems-Biology and Bioinformatics, 2017
Mohammad Kawsar Sharif Siam, Muhammad Sameer Hossain, E. Kabir, Samiul Alam Rajib   +3 more
semanticscholar   +1 more source

FOLIC ACID AND ANTAGONISTS IN NEOPLASTIC DISEASE

The American Journal of the Medical Sciences, 1949
J B, THIERSCH, F S, PHILIPS
openaire   +2 more sources

Folic acid Antagonists and Chromosomal Abnormalities.

British Journal of Dermatology, 1965
T J, RYAN, M M, BODDINGTON, A I, SPRIGGS
openaire   +2 more sources

Neural tube defects in relation to use of folic acid antagonists during pregnancy.

American Journal of Epidemiology, 2001
S. Hernández-Díaz, M. Werler, A. Walker, A. Mitchell   +3 more
semanticscholar   +1 more source