Results 91 to 100 of about 49,690 (146)

Comparison of Luteal Support Protocols in Frozen IVF/ICSI Cycles: A Network Meta‐Analysis

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Background Luteal support is a core success factor of frozen embryo transfers (FET). However, inconsistency across recommended protocols generates notable heterogeneity across reproductive outcomes. Objective To determine the most effective luteal support strategy (LPS) based on five key factors related to the effectiveness of FET cycles ...
Neerujah Balachandren, Meenakshi Veeramani, Sureka Suriyakumar, Sarah Wiley, Dimitrios Mavrelos, Ephia Yasmin, Stavroula L. Kastora   +6 more
wiley   +1 more source

Inactivation of Histone Chaperone HIRA Unmasks a Link Between Normal Embryonic Development of Melanoblasts and Maintenance of Adult Melanocyte Stem Cells

Aging Cell, EarlyView.
Expression of HIRA in embryonic melanoblasts is required for proper epigenetic programing and lineage differentiation. Although HIRA deficiency results in a mild phenotype at birth and young adulthood, the melanocytic lineage is sensitive to proliferative challenge, prone to loss of stem cells and dramatically accelerated hair greying in later life ...
Farah Jaber‐Hijazi, Rouven Arnold, Karthic Swaminathan, Kathryn Gilroy, Alexander T. Wenzel, Anthony Lagnado, Kristina Kirschner, Neil Robertson, Claire Reid, Neil Fullarton, Jeff Pawlikowski, Taranjit Singh Rai, Ian Baranyk, Christina Huan Shi, Kevin Y. Yip, Karen Blyth, Jill P. Mesirov, Melissa L. Harris, João F. Passos, Laura M. Machesky, Peter D. Adams   +20 more
wiley   +1 more source

A Comprehensive Multiomics Signature of Doxorubicin‐Induced Cellular Senescence in the Postmenopausal Human Ovary

Aging Cell, EarlyView.
Explants of human postmenopausal ovarian cortex and medulla were treated with doxorubicin for 24 h followed by culture for up to 10 days in doxorubicin‐free medium. Single nuclei sequencing and proteomics revealed an unbiased signature of ovarian senescence driven by epithelial cells in the cortex and stromal cells in the cortex and medulla ...
Pooja Raj Devrukhkar, Mark A. Watson, Bikem Soygur, Fei Wu, Joanna Bons, Hannah Anvari, Tomiris Atazhanova, Nicolas Martin, Tommy Tran, Kevin Schneider, Jacob P. Rose, Daniel Winer, Elisheva Shanes, Mary Ellen G. Pavone, Judith Campisi, David Furman, Simon Melov, Birgit Schilling, Francesca E. Duncan   +18 more
wiley   +1 more source

Circadian Gene BMAL1 Regulation of Cellular Senescence in Thyroid Aging

Aging Cell, EarlyView.
BMAL1 downregulation during aging reduces NFKBIA expression, accelerating thyroid cellular senescence and impairing hormone synthesis. Circadian rhythm disruption exacerbates thyroid functional decline, highlighting the BMAL1‐NFKBIA axis as a key mediator of aging‐related thyroid dysfunction and offering insights for stabilizing thyroid health in aging
Dandan Zong, Baihui Sun, Qiting Ye, Hongxin Cao, Haixia Guan   +4 more
wiley   +1 more source

GnRH-agonist implants suppress reproductive function and affects ovarian LHR and FSHR expression in prepubertal female cats [PDF]

, 2017
Axner, Bristol-Gould, Brown, Brown, Carranza, Carranza, Chatdarong, Chowdhury, Faya, Goericke-Pesch, Goodrowe, Gudermuth, Ishibashi, Johnston, Kelly, Kinoshita, M. Khalid, Munson, N.S. Mehl, Orosz, Pelican, Pelican, Ponglowhapan, Ponglowhapan, Ponglowhapan, Risso, S. Sirivaidyapong, S. Srisuwatanasagul, Saint-Dizier, Sano, T. Swangchan-Uthai, Tharasanit, Toydemir, Trigg, Wright   +34 more
core   +1 more source

Biomarkers of Cellular Senescence in Type 2 Diabetes Mellitus

Aging Cell, EarlyView.
In cohorts of lean controls, obese participants without Type 2 Diabetes Mellitus (T2DM) and obese T2DM participants, we find that T‐cell expression of senescence biomarkers is altered only in the T2DM participants and not with obesity alone. Moreover, high T‐cell p16 expression in the T2DM participants is associated with impaired bone cortical indices.
Caroline Hoong, Joshua N. Farr, David G. Monroe, Thomas A. White, Elizabeth J. Atkinson, Amanda Tweed, Allyson K. Palmer, Nathan K. LeBrasseur, Jad G. Sfeir, Sundeep Khosla   +9 more
wiley   +1 more source

The Effect of Assisted Reproductive Technologies on Human Sex Ratios

Australian and New Zealand Journal of Obstetrics and Gynaecology, EarlyView.
ABSTRACT Background Modern assisted reproductive technology (ART), including pre‐implantation genetic testing for aneuploidy (PGT‐A), has opened new avenues in understanding early embryonic events and has simultaneously raised questions about the impact of ART itself on sex ratios.
Ektoras X. Georgiou, Yossi Mizrachi, Rebecca Kelley, Sharyn Stock‐Myer, John Stevens, David K. Gardner, Alex Polyakov   +6 more
wiley   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Testicular histopathology and its association with germ cell numbers, serum concentrations of reproductive hormones, and semen quality

Andrology, EarlyView.
Abstract Background It is well‐established that spermatogenesis, semen quality, and reproductive hormones are interlinked. It is, however, less well‐described how various specific testicular histopathologies are linked to reproductive hormones and semen quality.
Gülizar Saritas, Nina Mørup, Trine H. Johannsen, Anders Juul, Lise Aksglaede, Sofia B. Winge, Kristian Almstrup   +6 more
wiley   +1 more source

Effects of AZFc (b2/b4, b1/b3, b2/b3, and gr/gr) deletions and primary duplications on the outcomes of the first intracytoplasmic sperm injection treatment cycle: A single‐center retrospective cohort study

Andrology, EarlyView.
Abstract Background Current advances in high‐throughput sequencing technology enable the precise identification of Y chromosome microdeletion and primary duplication in infertile couples, but the mechanism and clinical significance of these mutations in assisted reproductive techniques remain unclear.
Linlin Li, Xiangyin Liu, Xinying Wang, Hongguo Zhang, Ruizhi Liu   +4 more
wiley   +1 more source