Single‐nucleus RNA sequencing and functional profiling of goat ovaries with divergent litter sizes revealed prolificacy‐associated granulosa cell (GC) states characterized by enhanced proliferation‐ and steroidogenesis‐related features, together with altered predicted cell–cell communication.
Sanbao Zhang +6 more
wiley +1 more source
Effect of air pollution on clinical pregnancy outcomes following intrauterine insemination: a machine learning-based analysis. [PDF]
Guan Y +7 more
europepmc +1 more source
Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao +10 more
wiley +1 more source
Follicle Size Regulates Cytoplasmic Maturation, Lipid Content, and Embryo Cryosurvival in Bovine Oocytes Matured In-Vitro. [PDF]
Castro B +2 more
europepmc +1 more source
Lactobacillus johnsonii attenuates ovarian aging by remodeling the gut–ovary axis
Aging is accompanied by a reduced abundance of L. johnsonii and ovarian decline. Supplementation with L. johnsonii elevates microbial IPA production via the LdhA enzyme and commensal bacteria. IPA activates the AhR/YAP signaling axis, promoting YAP nuclear translocation and inducing the expression of downstream target genes CYR61 and CTGF. This cascade
Jiamin He +16 more
wiley +1 more source
Integrative mRNA and lncRNA Transcriptome Analysis of Skin Tissues with Different Coat Types in Cashmere Goats Across Stages of Hair Follicle Development. [PDF]
Zhang L +7 more
europepmc +1 more source
Thin endometrium upregulates Cxcl11, which polarizes ovarian macrophages via NF‐κB/AKT, impairing ovarian function. A new uter‐ovarian signaling axis is identified. ABSTRACT Objective Thin endometrium (TE) is a recognized cause of female infertility, primarily associated with impaired uterine receptivity.
Yulu Yang +8 more
wiley +1 more source
Tissue Clearing for Lymph Nodes: 3D Mapping of Nerves and the Immune Microenvironment
ABSTRACT Lymph nodes (LNs) are central hubs of adaptive immunity and key relay sites for metastatic tumour cells. However, conventional two‐dimensional histology samples only a small fraction of each node, potentially missing micrometastases and multifocal involvement while obscuring long‐range spatial relationships among tumour deposits, immune ...
Guang‐Hong Su +7 more
wiley +1 more source
Inhibin-Mediated Regulation of Folliculogenesis and Litter Size in Small Ruminants and Non-Ruminants. [PDF]
Ullah A +5 more
europepmc +1 more source

