Results 31 to 40 of about 60,431 (256)

Role of cysteine residues in the carboxyl-terminus of the follicle-stimulating hormone receptor in intracellular traffic and postendocytic processing

Frontiers in Cell and Developmental Biology, 2016
Posttranslational modifications occurring during the biosynthesis of G protein-coupled receptors include glycosylation and palmitoylation at conserved cysteine residues located in the carboxyl-terminus (Ctail) of the receptor.
Brenda Melo-Nava, Patricia Casas-González, Marco Pérez-Solís, Jean Castillo-Badillo, José L. Maravillas-Montero, Eduardo Jardón-Valadez, Teresa Zariñán, Arturo Aguilar-Rojas, Nathalie GALLAY, Eric Reiter, Alfredo Ulloa-Aguirre   +10 more
doaj   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Nanostructured transdermal hormone replacement therapy for relieving menopausal symptoms: a confocal Raman spectroscopy study

Clinics, 2014
OBJECTIVE: To determine the safety and efficacy of a transdermal nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) for relieving postmenopausal symptoms.
Marco Antonio Botelho, Dinalva Brito Queiroz, Gisele Barros, Stela Guerreiro, Pierre Fechine, Sonia Umbelino, Arao Lyra, Boniek Borges, Allan Freitas, Danilo Caldas de Queiroz, Ronaldo Ruela, Jackson Guedes Almeida, Lucindo Quintans Jr.   +12 more
doaj   +1 more source

Antral Follicles Count and Anti-Müllerian Hormone Levels after Gonadotoxic Chemotherapy in Patients with Breast Cancer: Cohort Study [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2017
Aim To assess ovarian reserve (OVR) by means of follicle-stimulating hormone (FSH), anti-Müllerian hormone (AMH), and antral follicle count (AFC) measurement in eumenorrheic women with breast cancer, exposed to gonadotoxic chemotherapy. Method Fifty-two
Ângela Marcon D'Avila, Edison Capp, Helena von Eye Corleta   +2 more
doaj   +1 more source

Effect of elevating luteinizing hormone action using low doses of human chorionic gonadotropin on double ovulation, follicle dynamics, and circulating follicle-stimulating hormone in lactating dairy cows

Journal of Dairy Science, 2022
: Double ovulation and twin pregnancy are undesirable traits in dairy cattle. Based on previous physiological observations, we tested the hypothesis that increased LH action [low-dose human chorionic gonadotropin (hCG)] before the expected time of ...
Victor E. Gomez-Leon, Adam D. Beard, O.J. Ginther, Milo C. Wiltbank   +3 more
doaj   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source

Impact of Endometriosis on Fertility Hormones and Ovarian Reserve Markers (AMH, FSH, LH)

Link Medical Journal of Health and Community Research
Background: Endometriosis is a chronic gynecological condition commonly affecting women of reproductive age and is frequently associated with infertility.
Ambreen Ibrahim, Naheed Shah, Lubna Malik, Rawaal Amin, Syeda Khalida Naeem, Hina Ali Ahmed   +5 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

The impact of infertility on serum heat shock protein 70, adropin and orexin levels in women: a case-control study

Mìžnarodnij Endokrinologìčnij Žurnal
Background. Infertility is a major reproductive health issue affecting millions of women worldwide. Recent studies have highlighted the potential roles of metabolic and neuroendocrine peptides, including heat shock protein 70 (HSP70), adropin and orexin,
Noor Jassem Mohammed, Nagham Qasim Kadhim, Sabbar Rashid Lateef, Mohammed R. Abed Al-Joubory, Saif M. Hasan, Inaam Faisal Mohammed   +5 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source