The potential role of NLRP3 inflammasome in integrating redox, metabolic, and inflammatory signals during follicular development: a hypothesis-driven redox-metabolic integrator framework [PDF]
Follicular development is a complex and dynamic biological process involving coordinated interactions among endocrine regulation, cellular metabolism, redox homeostasis, mitochondrial function, and immune signaling.
Zhenghong Zhang +5 more
doaj +2 more sources
Perifollicular stromal cells sustain folliculogenesis via MDK–NCL signaling in mice and humans [PDF]
Oocyte development requires coordinated metabolic and signaling support from granulosa and theca cells. By performing integrated single-cell RNA sequencing and spatial transcriptomic analyses of murine and human ovaries, we discovered a functionally ...
Zhe Zhang +17 more
doaj +2 more sources
Immunological dysregulation of follicular helper T cells, follicular regulatory T cells, and follicular cytotoxic T cells is associated with disease activity and identifies exploratory immune patterns in rheumatoid arthritis [PDF]
BackgroundThe onset and progression of rheumatoid arthritis (RA) are linked to autoantibody production driven by dysregulated germinal center (GC) responses. Follicular helper T cells (Tfh), follicular regulatory T cells (Tfr), and follicular cytotoxic T
Yuxin Fan +21 more
doaj +2 more sources
Comprehensive multi-omics reveals dynamic chromatin changes and gene regulatory networks during duck folliculogenesis [PDF]
Background Follicular development is a prerequisite for vertebrate reproduction, and it is precisely regulated by complex genomic conformations and regulatory elements.
Zhen Li +5 more
doaj +2 more sources
Dynamic Predictors for Malignancy Risk of Follicular Thyroid Neoplasms: A Real‐World, 10‐Year Cohort Study [PDF]
Objective The malignancy risk of follicular thyroid neoplasms (FTN) is variable, yet most studies rely on static, single‐time‐point assessments without monitoring dynamic changes.
Rui Shan +14 more
doaj +2 more sources
Regulation of ovarian function in domestic animals: translational insights into human ovarian dynamics and dysfunction [PDF]
Ovarian follicular development is a tightly regulated, dynamic process coordinated by endocrine, paracrine, neuroendocrine, and vascular mechanisms that together determine follicle recruitment, selection, dominance, and ovulation. In monovulatory mammals,
Dinesh Dadarwal, Rodrigo A. Carrasco
doaj +2 more sources
Follicular dynamics in Serrana goats [PDF]
Twenty-two Serrana goats were studied through two successive estrous cycles in order to characterize their follicular dynamics during the breeding season. The ovaries of the goats were scanned daily by real-time ultrasonography and all follicles >or=3mm were measured and classified. The data were classified by the number of follicular waves per goat to
Valentim, Ramiro +6 more
openaire +5 more sources
Multiple Insulin Injections to Improve Ovarian Activity and Pregnancy of Repeat Breeder Friesian Cows حقنات الأنسولين المتعددة لتحسين النشاط المبيضى والحمل فى الأبقار الفريزيان المتکررة التلقيح [PDF]
This study aimed to evaluate the effect of exogenous multiple insulin injections on ovarian and estrus activity, and pregnancy rate in repeat breeder Friesian cows. Cows (n=12) in heat (Day 0) were divided into three groups.
W. Fouad +3 more
doaj +1 more source
The activins and inhibins are glycoproteins with a role in the follicular development of vertebrates, that are found in follicular fluid and somatic follicular cells, with a different pattern among taxa.
N.B. Cruz-Cano +5 more
doaj +1 more source
Inflammation and Human Ovarian Follicular Dynamics [PDF]
Inflammation is a biologic process that mediates tissue effects including vasodilation, hyperemia, edema, collagenolysis, and cell proliferation through complex immunologic pathways. In regard to the ovary, inflammation has key physiologic roles in ovarian folliculogenesis and ovulation.
Christina E, Boots, Emily S, Jungheim
openaire +2 more sources

