Results 41 to 50 of about 55,852 (309)

Gonadotropin-Releasing Hormone (GnRH) and Its Agonists in Bovine Reproduction I: Structure, Biosynthesis, Physiological Effects, and Its Role in Estrous Synchronization

Animals
GnRH is essential for the regulation of mammalian reproductive processes. It regulates the production and release of pituitary gonadotropins, thereby influencing steroidogenesis and gametogenesis.
Eman M. Hassanein, Zoltán Szelényi, Ottó Szenci   +2 more
doaj   +1 more source

IgM and IgD B cell receptors differentially respond to endogenous antigens and control B cell fate. [PDF]

, 2018
Naive B cells co-express two BCR isotypes, IgM and IgD, with identical antigen-binding domains but distinct constant regions. IgM but not IgD is downregulated on autoreactive B cells. Because these isotypes are presumed to be redundant, it is unknown how
Brombacher, Frank, Garrett-Sinha, Lee Ann, Mueller, James L, Noviski, Mark, Satterthwaite, Anne, Zikherman, Julie   +5 more
core   +3 more sources

Inventory of personal factors influencing conditioned pain modulation in healthy people: a systematic literature review [PDF]

, 2015
Background: Conditioned pain modulation (CPM) is believed to play an important role in the development and exacerbation of chronic pain, because dysfunction of CPM is associated with a shift in balance between pain facilitation and pain inhibition.
Calders, Patrick, Crombez, Geert, Goubert, Dorien, Goudman, Lisa, Hermans, Linda, Meeus, Mira, Van Oosterwijck, Jessica   +6 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Regulation of reproduction via tight control of gonadotropin hormone levels. [PDF]

, 2018
Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH, which then control steroidogenesis and gametogenesis. In females, serum LH and FSH
Coss, Djurdjica
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells

Frontiers in Immunology, 2020
Fibroblastic reticular cells (FRCs) are the specialized lymphoid stromal cells initially identified as triggering T-cell recruitment and dynamic motion in secondary lymphoid organs.
Jan Misiak, Rachel Jean, Rachel Jean, Stéphane Rodriguez, Laurent Deleurme, Laurent Deleurme, Thierry Lamy, Thierry Lamy, Karin Tarte, Karin Tarte, Patricia Amé-Thomas, Patricia Amé-Thomas   +11 more
doaj   +1 more source

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration [PDF]

, 2008
In the age of stem cell engineering it is critical to understand how stem cell activity is regulated during regeneration. Hairs are mini-organs that undergo cyclic regeneration throughout adult life1, and are an important model for organ regeneration ...
A Durward, AE Oro, C Blanpain, C Lo Celso, Cheng-Ming Chuong, Damon de la Cruz, E Fuchs, E Johnson, EA Sausville, FJ Ebling, H Chase, J Huelsken, J Zhang, Julie Ann Mayer, K Kobielak, K Militzer, KA Moore, KS Stenn, L Ma, M Iguchi, M Maurer, M Plikus, Maksim V. Plikus, N Suzuki, P Wu, Philip K. Maini, R Paus, RJ Morris, Robert Maxson, Ruth E. Baker, S Reddy, VA Botchkarev, VA Botchkarev, WE Lowry, XC He, Y Zheng   +35 more
core   +2 more sources

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Mesenchymal stromal cells support the viability and differentiation of follicular lymphoma-infiltrating follicular helper T-cells. [PDF]

PLoS ONE, 2014
The biology of follicular lymphoma (FL) is largely dictated by the immune-effector and stromal cells that comprise its tumor microenvironment. FL-infiltrating T-cell populations that are thought to be fundamental to FL biology are follicular helper T ...
Michael T Brady, Shannon P Hilchey, Ollivier Hyrien, Stephen A Spence, Steven H Bernstein   +4 more
doaj   +1 more source