Results 51 to 60 of about 55,852 (309)
Three-Dimensional Telomere Dynamics in Follicular Thyroid Cancer [PDF]
Thyroid, 2014 Over the last decade, annual incidence rates for thyroid cancer have been among the highest of all cancers in the Western world. However, the genomic mechanisms impacting thyroid carcinogenesis remain elusive.We employed an established mouse model of follicular thyroid cancer (FTC) with a homozygous proline to valine mutation (Thrb(PV/PV)) in the ...
Landon, Wark +7 more
openaire +2 more sources
Constitutively active transforming growth factor β receptor 1 in the mouse ovary promotes tumorigenesis [PDF]
, 2016 Despite the well-established tumor suppressive role of TGFβ proteins, depletion of key TGFβ signaling components in the mouse ovary does not induce a growth advantage.
Bartholin, Laurent +5 more
core +1 more source
Three‐Dimensional Ovary Model to Improve and Study Murine Follicle Growth
Advanced Healthcare Materials, EarlyView.To develop new methods for fertility preservation in women, novel culture systems for small follicles need to be established. In this work, a poly(ethylene glycol) based scaffold, with appropriate mechanical and bioactive features to support mouse follicle and ovary cell growth is developed, and the formed cell‐follicle interactions are visualized ...
Mira Jacobs +6 more
wiley +1 more source
Scientific Reports, 2022 Histological sections of the lymphatic system are usually the basis of static (2D) morphological investigations. Here, we performed a dynamic (4D) analysis of human reactive lymphoid tissue using confocal fluorescent laser microscopy in combination with ...
Patrick Wagner +12 more
doaj +1 more source
NFE2-Related transcription factor 2 coordinates antioxidant defense with thyroglobulin production and iodination in the thyroid gland [PDF]
, 2018 Background: The thyroid gland has a special relationship with oxidative stress. While generation of oxidative substances is part of normal iodide metabolism during thyroid hormone synthesis, the gland must also defend itself against excessive oxidation ...
Amendola, Elena +19 more
core +1 more source
Advanced Healthcare Materials, EarlyView.We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham +11 more
wiley +1 more source
SportsMaximal strength is a significant factor in achieving peak performance and injury prevention in athletes. In individualization strategies for the efficient development of athletes, it is necessary to consider the respective components separately.
Marc Niering +6 more
doaj +1 more source
Frontiers in Immunology, 2018 An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to ...
Nicolas Fazilleau +7 more
doaj +1 more source
Reproductive physiology of the female cat [PDF]
, 2003 Ovarian cyclicity induces considerable changes in morphology, physiology and function of the reproductive organs in animals. This thesis aimed to study reproductive physiology of the female domestic cat, focusing on the cervix, uterus and uterine tube ...
Chatdarong, Kaywalee
core
Maintenance of head and neck tumor on-chip: gateway to personalized treatment? [PDF]
, 2017 Aim: Head and neck squamous cell carcinomas (HNSCC) are solid tumors with low overall survival (40–60%). In a move toward personalized medicine, maintenance of tumor biopsies in microfluidic tissue culture devices is being developed. Methodology/ results:
Bower, Ruth +7 more
core +1 more source