Results 81 to 90 of about 30,611 (293)

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Diversity of Extracellular Vesicles in Human Follicular Fluid: Morphological Analysis and Quantification

, 2022
The oocyte microenvironment constituted by the follicular fluid (FF) is a key for the optimal development of female gametes. Its composition reflects the physiological state of the ovarian follicle.
Ducarre, Solène, Solène Ducarre, Claire Heichette, Moulin, Gregory, Valérie Marchi, Budzynski, Mathieu, Regina Maria Chiechio, Chiechio, Regina Maria, Even-Hernandez, Pascale, Lo Faro, Maria, Josè, Gregory Moulin, Aurélien Dupont, Yefimova, Marina, Pascale Even-Hernandez, Marchi, Valérie, Ravel, Célia, Anne-Sophie Neyroud, Dupont, Aurélien, Mathieu Budzynski, Marina Yefimova, Heichette, Claire, Faro, Maria Jose Lo, Célia Ravel, Neyroud, Anne-Sophie, Maria Jose Lo Faro   +24 more
core   +1 more source

The ATA 2025 histotype-based risk stratification of differentiated thyroid cancer: the revenge of morphologic pathology?

Oncologie
Differentiated thyroid cancer (DTC), encompassing papillary and follicular carcinomas, is the most common endocrine malignancy worldwide. Although incidence has increased, largely due to expanded imaging and diagnostic scrutiny, disease-specific ...
Giovanella Luca, Bongiovanni Massimo
doaj   +1 more source

Postpartum uterine and ovarian condition affect the foal estrus fertility in Mangalarga Marchador mares?

Acta Scientiarum: Animal Sciences
This study was conducted to evaluate the follicle development, uterine morphology, and fertility of Mangalarga Marchador mares submitted to natural breeding in the first postpartum estrous cycle.
Hanna Gabriela Oliveira Maia, Lúcio Tolentino Amaral Júnior, Felipe Gomes da Silva, Gustavo Leal Teixeira, Neide Judith Faria de Oliveira, Letícia Ferrari Crocomo   +5 more
doaj   +1 more source

SpaMode: A Broadly Applicable Framework for Deciphering Spatial Multi‐Omics Using Multimodal Mixture of Disentangled Experts

Advanced Science, EarlyView.
SpaMode introduces a versatile framework for spatial multi‐omics integration across vertical, horizontal, and mosaic scenarios. By disentangling modality‐invariant and variant features through a mixture‐of‐experts mechanism, it adaptively reconfigures spatially heterogeneous signals.
Xubin Zheng, Xinlei Huang, Xiang Zhou, Dian Meng, Ziyue Qiao, Zhiyuan Yuan, Lixin Cheng   +6 more
wiley   +1 more source

Natural Resistance to Ovarian Hyperstimulation Syndrome in Estrildid Finches Reveals Macrophage GPR183 as a Potential Therapeutic Target

Advanced Science, EarlyView.
Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan, Yongjie Huang, Jiabao Yang, Su Ma, Songsong Liu, Xuan Huang, Juergen Brosius, Huaping Zheng, Bing Yao, Li Chen, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

A methodological and functional proteomic approach of human follicular fluid en route for oocyte quality evaluation

, 2013
Follicular fluid is characterized by a vast protein complexity and a broad dynamic range of protein abundances that hinder its analysis. In this study we determined a proper solubilization and resolution method of HFF in 2-DE, minimizing sample ...
Gagliardi, A., Carleo, A., Piomboni, P., Bini, L., Bianchi, L., Armini, A., Focarelli, R., De Leo, V., Campanella, G., Landi, C., Capaldo, A.   +10 more
core   +1 more source

Rewiring NADH Metabolism Through NQO1‐Mediated Redox Cycling for Targeted Follicular Lymphoma Therapy

Advanced Science, EarlyView.
ABSTRACT Follicular lymphoma (FL) remains an incurable B‐cell malignancy with high relapse rates, and conventional therapies are often limited by significant toxicity, highlighting the need for novel treatments. We identified that FL exhibits markedly low expression of NAD(P)H: quinone oxidoreductase 1 (NQO1), a key enzyme required for activating ...
Jinxing Zhang, Ziqi Wang, Ye Weng, Yulin Fu, Yuelong Jiang, Beilin Zhuang, Wenzi Zeng, Xiangchun Zhang, Bing Xu, Jie Zha, Hongjun Zhuang   +10 more
wiley   +1 more source

Decoding Spatial Heterogeneity and Multi‐Omics Regulation with Hierarchical Graph Learning

Advanced Science, EarlyView.
ABSTRACT Recent advances in spatial multi‐omics technologies have enabled the simultaneous profiling of multiple molecular layers within the same tissue slice, providing unprecedented opportunities to investigate tissue spatial organization. However, most existing computational methods identify spatial domains in a purely data‐driven manner, rarely ...
Jiazhou Chen, Jiahui Xie, Yi Liao, Junyu Li, Longqi Liu, Xin Gao, Hongmin Cai   +6 more
wiley   +1 more source

Effects of ovarian hormones and oral contraceptive pills on cardiac vagal withdrawal at the onset of dynamic exercise.

PLoS ONE, 2015
The purpose of this study was to investigate the effects of the ovarian hormones and the use of oral contraceptive pills (OCP) on cardiac vagal withdrawal at the onset of dynamic exercise. Thirty physically active women aged 19-32 years were divided into
André L Teixeira, Plinio S Ramos, Lauro C Vianna, Djalma R Ricardo   +3 more
doaj   +1 more source