Results 81 to 90 of about 55,852 (309)

Molecular mechanism of follicular development in laying hens based on the regulation of water metabolism

Open Life Sciences
The graphical abstract above outlines the research plan of the study, summarizing the key stages involved in investigating the molecular mechanisms of water metabolism in laying hens and their effect on follicular development.
Chen Xiaoxia, Lyu Shuchen, Zhou Huimin, Zou Xianqun, Yu Jing, Liu Yongjie   +5 more
doaj   +1 more source

Protective role of follicular CXCR5+CD8+ T cells against dengue virus 2 infection

International Journal of Infectious Diseases, 2019
Follicular CXCR5+CD8+ T cells have antiviral effects in chronic virus infection, but the roles of these cells during dengue virus 2 (DENV2) infection remain poorly understood.
Liannv Qiu, Hong Wang, Qinhua Yu, JieJing Liu, Sufeng Chen, Zhao Zhao   +5 more
doaj   +1 more source

Development and function of protective and pathologic memory CD4 T cells [PDF]

, 2015
Immunological memory is one of the defining features of the adaptive immune system. As key orchestrators and mediators of immunity, CD4 T cells are central to the vast majority of adaptive immune responses.
Jaigirdar, Shafqat Ahrar, Macleod, Megan K.L.   +1 more
core   +3 more sources

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

miRNA profiling of chicken follicles during follicular development

Scientific Reports
MicroRNAs (miRNAs) play a crucial role as transcription regulators in various aspects of follicular development, including steroidogenesis, ovulation, apoptosis, and gene regulation in poultry.
Zhongxian Xu, Qian Liu, Chunyou Ning, Maosen Yang, Qing Zhu, Diyan Li, Tao Wang, Feng Li   +7 more
doaj   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Postpartum uterine and ovarian condition affect the foal estrus fertility in Mangalarga Marchador mares?

Acta Scientiarum: Animal Sciences
This study was conducted to evaluate the follicle development, uterine morphology, and fertility of Mangalarga Marchador mares submitted to natural breeding in the first postpartum estrous cycle.
Hanna Gabriela Oliveira Maia, Lúcio Tolentino Amaral Júnior, Felipe Gomes da Silva, Gustavo Leal Teixeira, Neide Judith Faria de Oliveira, Letícia Ferrari Crocomo   +5 more
doaj   +1 more source

LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice [PDF]

, 2015
Mammalian oocytes are arrested at prophase I until puberty when hormonal signals induce the resumption of meiosis I and progression to meiosis II.
Chen, T, Kerenyi, MA, Kim, J, Lin, K, Lu, Y, Orkin, SH, Shen, J, Singh, AK, Takata, Y   +8 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source