Results 101 to 110 of about 29,881 (260)

Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury

Advanced Science, EarlyView.
After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez, Nicholas Basista, Sudhanshu Mishra, Hyeri Kim, Audrey Bench, Catherine Matte‐Martone, Min‐Soo Seo, Gun Woo Lee, Sangbum Park   +8 more
wiley   +1 more source

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

B Cells are Activated via a Nanoporous Interface that Stabilizes Microvilli and Engages Mechanosensitive Ion Channels

Advanced Science, EarlyView.
B cells can be activated independently of antigen recognition via mechanical stimulation through nanoporous substrates. Exposure to such substrates induced B cell microvilli extension into the pores, intracellular Ca2+ signaling, phosphorylation of signaling proteins, and CD69 expression.
Nozie D. Aghaizu, Willi Weber, Nadine Strempel, Asya Polat, Enrico Klotzsch   +4 more
wiley   +1 more source

Neuromedin B drives goat granulosa cell proliferation via NMBR-mediated calcium homeostasis

Journal of Ovarian Research
Background Neuromedin B (NMB) has been implicated in the regulation of female reproductive functions, yet its precise role and underlying mechanisms in ovarian follicular development remain undefined. Granulosa cells (GCs), the principal functional cells
Rongxin Xia, Qi Zhang, Junhui Shao, Yuan Wang, Xinyi Lv, Rui Chen, Zhen Lu, Yanli Zhang, Feng Wang, Guomin Zhang   +9 more
doaj   +1 more source

Functional Sex Reversal in Adult Gonochoristic Teleosts is Mediated by Ovarian Germline Stem Cell Plasticity and Somatic Cell Transdifferentiation

Advanced Science, EarlyView.
Oocytes play crucial roles in maintaining ovarian fate in adult gonochoristic fish. Targeted oocyte ablation with aromatase inhibition triggers the activation of surviving germline stem cells and the transdifferentiation of somatic cells from granoulosa/theca to Sertoli/Leydig lineages, inducing a complete and functional female‐to‐male sex reversal ...
Yang Yang, Liechao Yu, Wanchang Zhang, Gary Wessel, Ruiyi Chen, Weihua Hu, Dongdong Xu   +6 more
wiley   +1 more source

An Innervated Human Skin Equivalent that Electrically Encodes Mechanical and Thermal Stimuli

Advanced Science, EarlyView.
An innervated human skin equivalent is integrated with high‐density microelectrode arrays to reveal how engineered free nerve ending–like structures translate touch and temperature into electrical codes. Mechanical indentation and thermal stimulation engage the engineered somatosensory circuitry and evoke distinct firing and waveform signatures ...
Daniele Bellantoni, Costantino Casale, Marika Sperduti, Nevio L. Tagliamonte, Giorgia Imparato, Loredana Zollo, Paolo A. Netti   +6 more
wiley   +1 more source

Single‐Cell Profiling Reveals a Protective WNT5A‐ATF3‐FOSB Signaling Axis in Hair Follicle Stem Cells During Androgenetic Alopecia

Advanced Science, EarlyView.
Androgenetic alopecia (AGA) is a common form of hair loss with limited treatment options. Silencing of WNT5A signaling, which is widely known as the trigger of the ncWNT signaling pathway, happens in hair follicle stem cells from balding areas. It leads to downregulation of ATF3 and its target FOSB.
Ruiyu Luo, Ke Fang, Changjiang Zhao, Jiachao Xiong, Yuan Zhu, Mingyang Lu, He Yan, Zihan Li, Baojin Wu, Hua Jiang, Yufei Li   +10 more
wiley   +1 more source

Establishment and characterization of mouse lymph node fibrosis models

Animal Models and Experimental Medicine, EarlyView.
The design of the entire paper. Schematic illustration of four strategies for establishing mouse lymph node (LN) fibrosis models. The study further compares their fibrotic remodeling patterns and immune alterations. Abstract Background Lymph node (LN) fibrosis occurs in a variety of pathological conditions, including HIV infection, obesity, cancer, and
Yaru Niu, Xu Guan, Jian Ma, Xin Zhang, Yihang Shi, Jinzhu Zhang, Leiqiong Gao, Wei Chen, Xishan Wang   +8 more
wiley   +1 more source

A modified D‐galactose‐induced aging rat model with low‐dose intraperitoneal ozone: Redox, functional, and skin outcomes

Animal Models and Experimental Medicine, EarlyView.
Male Wistar rats were subjected to d‐galactose‐induced aging, with or without intermittent low‐dose intraperitoneal ozone administration, and evaluated over 8 weeks for redox status and physical performance, including physical health score, morbidity proportion, body weight, muscle strength, hair regrowth, and skin outcome.
Isabella Kurnia Liem, Raisa Nauli, Firda Asma’ul Husna, Sasanthy Kusumaningtyas, Deswaty Furqonita, Ferbian Milas Siswanto, Soegianto Ali   +6 more
wiley   +1 more source

Extracellular Vesicles From Follicular Fluid in Infertile Women: Size, Morphology and miRNA Content Analysis

Journal of Extracellular Biology
The declining birth rates and fertility challenges in Europe have intensified global concerns over rising infertility, particularly among women. This study decisively investigates follicular fluid‐related extracellular vesicles (FF‐EVs) from infertile ...
Solène Ducarre, Regina Maria Chiechio, Gregory Moulin, Ester Butera, Aurélien Dupont, Christophe Penno, Abdelhak El Amrani, Claire Heichette, Pascale Even‐Hernandez, Valérie Marchi, Célia Ravel   +10 more
doaj   +1 more source