Results 101 to 110 of about 7,109,986 (349)

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Lack of associations between female hormone levels and visuospatial working memory, divided attention and cognitive bias across two consecutive menstrual cycles [PDF]

, 2017
Background: Interpretation of observational studies on associations between prefrontal cognitive functioning and hormone levels across the female menstrual cycle is complicated due to small sample sizes and poor replicability. Methods: This observational
Egli, Marcel, Geraedts, Kirsten, Hengartner, Michael P., Ille, Fabian, Kruger, Tillmann H. C., Leeners, Brigitte, Mancini, Toni, Rã¶blitz, Susanna, Saleh, Lanja, Schippert, Cordula, Spanaus, Katharina, Tronci, Enrico, Zhang, Yuangyuang   +12 more
core   +4 more sources

Landscape transcriptomic analysis of bovine follicular cells during key phases of ovarian follicular development

Biological Research
Abstract Background There are many gaps in our understanding of the mechanisms involved in ovarian follicular development in cattle, particularly regarding follicular deviation, acquisition of ovulatory capacity, and preovulatory changes.
Henry David Mogollón García, Rodrigo de Andrade Ferrazza, Julian Camilo Ochoa, Flávia Florencio de Athayde, Pedro Marcus Pereira Vidigal, Milo Wiltbank, John Patrick Kastelic, Roberto Sartori, João Carlos Pinheiro Ferreira   +8 more
openaire   +4 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Effects of Menstrual Cycle on Exercise Treadmill Parameters and Cardiac Troponin Release in Premenstrual Women

Diagnostics
Background: The diagnostic accuracy of the exercise treadmill test (ETT) remains suboptimal in premenopausal women. Menstrual cycle phases display hormonal variations and biological effects in premenopausal women.
Aysu Oktay, Inanc Torustag, Ferruh Kemal Isman, Mehmet Agirbasli   +3 more
doaj   +1 more source

Species-specific differences in follicular antral sizes result from diffusion-based limitations on the thickness of the granulosa cell layer

, 2013
The size of mature oocytes is similar across mammalian species, yet the size of ovarian follicles increases with species size, with some ovarian follicles reaching diameters more than 1000-fold the size of the enclosed oocyte.
Bächler, M., De Geyter, Ch., Iber, D., Menshykau, D.   +3 more
core   +1 more source

Opportunities for topical antimicrobial therapy: permeation of canine skin by fusidic acid [PDF]

, 2017
BACKGROUND: Staphylococcal infection of the canine epidermis and hair follicle is amongst the commonest reasons for antimicrobial prescribing in small animal veterinary practice.
A Loeffler, A Loeffler, Anette Loeffler, BK Valentine, D Bommannan, DH Lloyd, DH Lloyd, DH Lloyd, DJ Davies, G Stuttgen, GH Nesbitt, H Löffler, I Degim, IS Mason, JD Bos, JF Summers, Jo Larner, JT Headington, K Brain, KM Credille, LA Ahlstrom, LA Ahlstrom, LE Berrutti, MA Cobb, NA Monteiro-Riviere, PM Elias, Ross Bond, RS Mueller, Sian-Marie Frosini, SM Clark   +29 more
core   +5 more sources

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Biometrical parameters of internal female genitalia in western Libyan Barbary sheep

Open Veterinary Journal
Background: In Libya, the Barbary sheep plays an important role in livestock as a source of meat and wool. Improving animal production requires knowledge and understanding of the female reproductive system.
Farg Alhadi Aboashia, Fatma Ayad Alatrag, Aboulgasem Ahmed Elmarimi, Abdalhalim Meloud Suaiee   +3 more
doaj   +1 more source

Effects of superstimulation with fsh on follicular population and recovery rate of oocytes in the growing phase of the first and second follicular wave

Veterinární Medicína, 2002
Effectiveness of in vitro production of embryos (IVP) is limited among other factors by the recovery rate of oocytes. Gonadotropin superstimulation can improve the recovery rate of oocytes.
S. Čech, V. Havlíček, M. Lopatářová, M. Vyskočil, R. Doležel   +4 more
doaj   +1 more source