Results 101 to 110 of about 108,042 (237)
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
ON THE USE OF PRODUCTIVITY-INCREASING TECHNOLOGIES IN SUB-SAHARAN AFRICA: THE CASE OF INLAND VALLEY SWAMP RICE FARMING IN SOUTHERN MALI [PDF]
There is no improved seed-fertilizer technology available that can generate the needed growth in agricultural production in Sub-Saharan Africa to meet food demand by the rapidly increasing population.
Simpara, M. +5 more
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Vojnotehnički Glasnik, 2014 Najnovija kineska podmornica klase Yuan; U toku je testiranje ruskog tenka Armata; Indija prikazuje modernizovanu verziju tenka Arjun Mk II; Podmornica klase Andrasta za obalne vode Južne Azije; Indija je uspešno testirala domaću raketu vazduh-vazduh ...
Dragan M. Vučković
doaj
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
An Inordinate Fondness of Rarity
PLoS Biology, 2013 In evolutionary biologist circles, J.B.S. Haldane's quip to a theologian that from his studies, he has learned God has an “inordinate fondness of beetles”, is a perennial favorite to quote, misquote and modify, even though it's unclear whether the encounter ever actually happened.
openaire +4 more sources
Cílem projektu METR bylo podpořit rozvoj sdílených pracovních míst, a to propojením tohoto konceptu s mezigeneračním učením. Šlo o analytický projekt, v jehož průběhu byla vyhodnocena systémová opatření i praktická využití těchto konceptů v ČR a následně
Michaela Šimečková +2 more
core +1 more source