Results 91 to 100 of about 102,953 (306)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Characteristics of patients suspected of having COVID-19 and the outcomes of their visits to the COVID outpatient clinic [PDF]
Opšta MedicinaIntroduction. The COVID-19 patients were treated in outpatient clinics at primary healthcare centers, which alleviated the pressure on secondary and tertiary healthcare levels. Objective.
Petrov Kiurski Miloranka Đ.
doaj +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
"Fondul Secret" după decembrie 1989. [PDF]
, 1995 "Fondul Secret" după decembrie 1989.. - In: Fond secret, Fond "S" special : contribuţii la istoria fondurilor secrete de bibliotecă din România : studiu de caz : Biblioteca Centrală Universitară "Lucian Blaga" Cluj-Napoca, an 1995, p.
Radosav, Doru
core
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
FINANCIAL PROFITABILITY OF MALI-SUD BAS-FOND RICE PRODUCTION SYSTEMS
The high costs of rehabilitating and/or expanding government-managed irrigated schemes in Mali (Office du Niger) has prompted policy-makers and researchers to explore the potential for the underdeveloped farmer-managed bas-fond to contribute to ensure an
Mariko, Dramane +5 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Cílem projektu METR bylo podpořit rozvoj sdílených pracovních míst, a to propojením tohoto konceptu s mezigeneračním učením. Šlo o analytický projekt, v jehož průběhu byla vyhodnocena systémová opatření i praktická využití těchto konceptů v ČR a následně
Michaela Šimečková +2 more
core +1 more source