Results 71 to 80 of about 102,953 (306)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Fond du Lac Band of Lake Superior Chippewa Wiidookaage cancer plan 2025 [PDF]

open access: yes
The Fond du Lac Wiidookaage Comprehensive Cancer Plan defines cancer control activities for the Fond du Lac Reservation through 2025. It was created through a collaboration of Fond du Lac stakeholders including the Reservation Business Committee (Tribal ...

core  

Stáže pro mladé zájemce o zaměstnání 2

open access: yes
Obecně k projektu: Projekt reagoval na nepříznivou situaci absolventů škol na trhu práce a reflektoval obsah strategie Evropské komise “Evropa 2020“. Hlavním cílem projektu bylo usnadnit budoucím absolventům transfer ze vzdělávacího systému na pracovní ...
Fond dalšího vzdělávání   +1 more
core   +1 more source

Incidence of professional stress and burnout syndrome in general physicians [PDF]

open access: yesOpšta Medicina, 2020
Introduction: Professional stress and burnout syndrome are widely spread among health professionals. Objective: Examine the incidence of professional stress in general physicians (GPs) and the risk of burnout syndrome. Method: A cross-sectional study was
Petrov-Kiurski Miloranka Đ.
doaj  

Fonds d’impact sanitaire

open access: yesJournal du Droit de la Santé et de l’Assurance - Maladie (JDSAM), 2022
Ayant pris une portée globale en 1995 dans le cadre des accords ADPIC, les brevets de produit d’une durée de 20 ans constituent le système dominant de l’humanité pour encourager les innovations. Protégeant le monopole sur l’innovation, ce système permet aux innovateurs de récolter des marges importantes ou des frais de licence auprès des premiers ...
openaire   +2 more sources

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

tre ELin in Wartime Bratislava: the Character of the Magazine and the Circumstances of Its lbblishing between the Years 1939 - 1944 [PDF]

open access: yesSlovenska Literatura, 2015
It was exactly seventy years ago when the art and literature monthly Elán, a project shared by poet and editor Ján Smrek and publisher Leopold Mazáč, was moved to the wartime capital of Slovakia.
Monika Kapráliková
doaj  

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