Results 71 to 80 of about 108,042 (237)

On the Actual Basis for Establishing the Boundaries of Cultural Heritage in the form of Places of Interest. Part 1

open access: yesAcademia: Архитектура и строительство, 2019
Disputes around such a type of cultural heritage object as "Places of Interest" have not ceased since the adoption, in 2002, of Federal Law No. 73-FZ "On objects of cultural heritage (historical and cultural monuments) of the peoples of the Russian ...
Eleonora A. Shevchenko   +1 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Establishing Good Laboratory Practice at Small Colleges and Universities

open access: yesJournal of Microbiology & Biology Education, 2017
Good Laboratory Practice (GLP) and Standard Operating Procedures (SOPs) provide guidelines for proper operation of equipment, maintenance and sanitation, reporting structures, and related activities.
Susan M. Bornstein-Forst
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Ethyl carbamate formation in sub-optimal wine storage conditions and influence of the yeast starter

open access: yesOENO One, 2013
Aim: To evaluate the potential risk of ethyl carbamate (EC) formation in wine by studying its production kinetics at sub-optimal storage temperatures. Methods and results: The kinetics of EC formation was investigated in 60 white wines obtained from 6 ...
Roberto Larcher   +4 more
doaj   +1 more source

Fonds d’impact sanitaire

open access: yesJournal du Droit de la Santé et de l’Assurance - Maladie (JDSAM), 2022
Ayant pris une portée globale en 1995 dans le cadre des accords ADPIC, les brevets de produit d’une durée de 20 ans constituent le système dominant de l’humanité pour encourager les innovations. Protégeant le monopole sur l’innovation, ce système permet aux innovateurs de récolter des marges importantes ou des frais de licence auprès des premiers ...
openaire   +2 more sources

Fond du Lac Band of Lake Superior Chippewa Wiidookaage cancer plan 2025 [PDF]

open access: yes
The Fond du Lac Wiidookaage Comprehensive Cancer Plan defines cancer control activities for the Fond du Lac Reservation through 2025. It was created through a collaboration of Fond du Lac stakeholders including the Reservation Business Committee (Tribal ...

core  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)

open access: yesJournal of Experimental & Clinical Cancer Research
Background We have recently shown extensive sequence and conformational homology between tumor-associated antigens (TAAs) and antigens derived from microorganisms (MoAs).
Beatrice Cavalluzzo   +12 more
doaj   +1 more source

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