Results 61 to 70 of about 102,953 (306)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Establishing Good Laboratory Practice at Small Colleges and Universities

Journal of Microbiology & Biology Education, 2017
Good Laboratory Practice (GLP) and Standard Operating Procedures (SOPs) provide guidelines for proper operation of equipment, maintenance and sanitation, reporting structures, and related activities.
Susan M. Bornstein-Forst
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Der Herren Stephan und Joseph von Montgolfier Versuche mit der von ihnen erfundenen aerostatischen Maschine, ein Auszug aus der französischen Beschreibung des Herrn Faujas de Saint-Fond

von Christoph Gottlieb von MurrOriginaltitel: Description des experiences de la machine aerostatique de MM.
Faujas de Saint-Fond, Barthélemy
core   +1 more source

Sumarni inventar fonda Bilježnici Vodnjana (1616/1825.1857/1945)

Vjesnik Istarskog Arhiva, 2010
Autorica predstavlja sumarni inventar za fond Bilježnici Vodnjana (1616/1826.1857/1945), a koji se čuva u Državnom arhivu u Pazinu pod identifikacijskom oznakom HR-DAPA-9.
Maja Cerić
doaj  

Ethyl carbamate formation in sub-optimal wine storage conditions and influence of the yeast starter

OENO One, 2013
Aim: To evaluate the potential risk of ethyl carbamate (EC) formation in wine by studying its production kinetics at sub-optimal storage temperatures. Methods and results: The kinetics of EC formation was investigated in 60 white wines obtained from 6 ...
Roberto Larcher, Sergio Moser, Ainhoa Usua Menolli, Loris Tonidandel, Giorgio Nicolini   +4 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Sumarni inventar fonda Mjesni narodni odbor Pazin 1947-1952

Vjesnik Istarskog Arhiva, 2014
Gradivo fonda Državnog arhiva u Pazinu HR-DAPA-194 nastalo je djelovanjem Mjesnog narodnog odbora Pazin koji je djelovao od srpnja 1947. do travnja 1952. sa sjedištem u Pazinu.
Hendi Hrelja
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Cross-reactive CD8+ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs)

Journal of Experimental & Clinical Cancer Research
Background We have recently shown extensive sequence and conformational homology between tumor-associated antigens (TAAs) and antigens derived from microorganisms (MoAs).
Beatrice Cavalluzzo, Marie Christine Viuff, Siri Amanda Tvingsholm, Concetta Ragone, Carmen Manolio, Angela Mauriello, Franco M. Buonaguro, Maria Lina Tornesello, Francesco Izzo, Alessandro Morabito, Sine Reker Hadrup, Maria Tagliamonte, Luigi Buonaguro   +12 more
doaj   +1 more source