Results 21 to 30 of about 1,815 (178)

Fonsecaea pedrosoi Sclerotic Cells: Secretion of Aspartic-Type Peptidase and Susceptibility to Peptidase Inhibitors [PDF]

Frontiers in Microbiology, 2018
Fonsecaea pedrosoi is a dematiaceous fungus and the main causative agent of chromoblastomycosis that is a chronic disease usually affecting the human skin and subcutaneous tissues, which causes deformations and incapacities, being frequently refractory ...
Vanila F. Palmeira, Vanila F. Palmeira, Fatima R. V. Goulart, Marcela Q. Granato, Daniela S. Alviano, Celuta S. Alviano, Lucimar F. Kneipp, André L. S. Santos, André L. S. Santos   +8 more
doaj   +2 more sources

Tratamento de infecção corneana causado pelo Fonsecaea pedrosoi: relato de caso [PDF]

Arquivos Brasileiros de Oftalmologia, 2005
To report an unusual case of fungus keratitis due to Fonsecaea pedrosoi that developed after corneal trauma. Case report: A 18-year-old male presented with a corneal ulcer in the right eye, 28 days after a trauma with glass fragments.
Freitas, Denise de, Gené, Josepa, Godoy, Patricio, Guarro, Josep, Hofling-Lima, Ana Luisa, Romano, Andre C., Souza, Luciene Barbosa de, Zaror, Luis   +7 more
core   +7 more sources

Chromoblastomycosis Treatment With Combination Therapy of Itraconazole (Pulse Dose) and Cryotherapy [PDF]

Jurnal Profesi Medika, 2021
Chromoblastomycosis is a chronic mycosis infection of the skin and subcutaneous tissue. The lesson begins with a history of trauma characterized by slowly gradual growing nodule lesions, especially in the lower extremities.
Nugrohoaji Dharmawan, Ahmad Fiqri
doaj   +3 more sources

HIV Aspartic Peptidase Inhibitors Modulate Surface Molecules and Enzyme Activities Involved with Physiopathological Events in Fonsecaea pedrosoi [PDF]

Frontiers in Microbiology, 2017
Fonsecaea pedrosoi is the main etiological agent of chromoblastomycosis, a recalcitrant disease that is extremely difficult to treat. Therefore, new chemotherapeutics to combat this fungal infection are urgently needed.
Vanila F. Palmeira, Vanila F. Palmeira, Daniela S. Alviano, Lys A. Braga-Silva, Lys A. Braga-Silva, Fátima R. V. Goulart, Marcela Q. Granato, Sonia Rozental, Celuta S. Alviano, André L. S. Santos, André L. S. Santos, Lucimar F. Kneipp   +11 more
doaj   +2 more sources

Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production. [PDF]

PLoS Neglected Tropical Diseases, 2018
Fonsecaea pedrosoi (F. pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection ...
Bilin Dong, Zhongsheng Tong, Ruoyu Li, Sharon C-A Chen, Weihuang Liu, Wei Liu, Yao Chen, Xu Zhang, Yiqun Duan, Dongsheng Li, Liuqing Chen   +10 more
doaj   +2 more sources

In vitro susceptibility testing of Fonsecaea pedrosoi to antifungals [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1997
Based on the difficulties experienced in the treatment of chromoblastomycosis, 12 primary human isolates of F. pedrosoi, were tested for their in vitro susceptibility to various antimycotics.
Catalina de BEDOUT, Beatriz L. GÓMEZ, Angela RESTREPO   +2 more
doaj   +4 more sources

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans. [PDF]

PLoS ONE, 2014
Fonsecaea pedrosoi (F. pedrosoi), a major agent of chromoblastomycosis, has been shown to be recognized primarily by C-type lectin receptors (CLRs) in a murine model of chromoblastomycosis.
Bilin Dong, Dongsheng Li, Ruoyu Li, Sharon C-A Chen, Weihuang Liu, Wei Liu, Liuqing Chen, Yao Chen, Xu Zhang, Zhongsheng Tong, Yun Xia, Ping Xia, Yan Wang, Yiqun Duan   +13 more
doaj   +2 more sources

Widespread Verrucous Plaques of Chromoblastomycosis: A 12-Year Diagnostic Odyssey. [PDF]

Clin Case Rep
ABSTRACT Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue. This case underscores the critical importance of thorough laboratory investigations, particularly histopathology, in chronic dermatological conditions that mimic other granulomatous diseases.
Shrestha E, Sharma A, Gartaula M, Basnet A.   +3 more
europepmc   +2 more sources

Characterization of Fonsecaea pedrosoi melanin [PDF]

Journal of General Microbiology, 1991
The constituents of the melanin complex from mycelial forms of Fonsecaea pedrosoi were partially characterized. The pigment was mainly accumulated on large alkali-extractable, electron-dense cytoplasmic bodies (melanosomes) and, apparently, on the outer layer of the cell wall as external deposits within verrucose outgrowths.
C S, Alviano, S R, Farbiarz, W, De Souza, J, Angluster, L R, Travassos   +4 more
openaire   +2 more sources

The impact of AlphaFold Protein Structure Database on the fields of life sciences

PROTEOMICS, Volume 23, Issue 17, September 2023., 2023
Abstract Arguably, 2020 was the year of high‐accuracy protein structure predictions, with AlphaFold 2.0 achieving previously unseen accuracy in the Critical Assessment of Protein Structure Prediction (CASP). In 2021, DeepMind and EMBL‐EBI developed the AlphaFold Protein Structure Database to make an unprecedented number of reliable protein structure ...
Mihaly Varadi, Sameer Velankar
wiley   +1 more source