Results 31 to 40 of about 846 (138)

Single-cell RNA sequencing unravels T cell exhaustion underlying the chronicity of chromoblastomycosis [PDF]

Frontiers in Immunology
IntroductionChromoblastomycosis (CBM) is a chronic, neglected tropical fungal infection. Its immunopathogenesis, particularly the mechanism underlying its chronicity, remains poorly understood.MethodsWe performed single-cell RNA sequencing (scRNA-seq) on
Kexin Lei, Kexin Lei, Kexin Lei, Kexin Lei, Jie Tian, Jie Tian, Jie Tian, Jie Tian, Lu Zhang, Lu Zhang, Lu Zhang, Lu Zhang, Zhuoqing Gong, Zhuoqing Gong, Zhuoqing Gong, Zhuoqing Gong, Wenjie Liu, Wenjie Liu, Wenjie Liu, Wenjie Liu, Zhe Wan, Zhe Wan, Zhe Wan, Zhe Wan, Yang Wang, Yang Wang, Yang Wang, Yang Wang, Ruoyu Li, Ruoyu Li, Ruoyu Li, Ruoyu Li, Bilin Dong, Xiaowen Wang, Xiaowen Wang, Xiaowen Wang, Xiaowen Wang   +36 more
doaj   +2 more sources

Chromoblastomycosis due to Fonsecaea pedrosoi: an old wine in a rare bottle

Journal of Infection in Developing Countries, 2015
Chromoblastomycosis is a chronic subcutaneous mycosis commonly caused by Fonsecaea, Phialophora, and Cladophialophora spp. Out of these, Fonsecaea pedrosoi is the most common etiological agent, implicated in 70%–90% of the cases reported worldwide.
Sadia Khan, Anil Kumar, Vivek Vinod, Vivek Prabhakar, Malini Eapen, Jacob Thomas, Kavitha Dinesh, Shamsul Karim   +7 more
doaj   +4 more sources

Transformation of Fonsecaea pedrosoi into sclerotic cells links to the refractoriness of experimental chromoblastomycosis in BALB/c mice via a mechanism involving a chitin-induced impairment of IFN-γ production. [PDF]

PLoS Neglected Tropical Diseases, 2018
Fonsecaea pedrosoi (F. pedrosoi) is the most common agent of chromoblastomycosis. Transformation of this fungus from its saprophytic phase into pathogenic sclerotic cells in tissue is an essential link to the refractoriness of this infection ...
Bilin Dong, Zhongsheng Tong, Ruoyu Li, Sharon C-A Chen, Weihuang Liu, Wei Liu, Yao Chen, Xu Zhang, Yiqun Duan, Dongsheng Li, Liuqing Chen   +10 more
doaj   +2 more sources

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans. [PDF]

PLoS ONE, 2014
Fonsecaea pedrosoi (F. pedrosoi), a major agent of chromoblastomycosis, has been shown to be recognized primarily by C-type lectin receptors (CLRs) in a murine model of chromoblastomycosis.
Bilin Dong, Dongsheng Li, Ruoyu Li, Sharon C-A Chen, Weihuang Liu, Wei Liu, Liuqing Chen, Yao Chen, Xu Zhang, Zhongsheng Tong, Yun Xia, Ping Xia, Yan Wang, Yiqun Duan   +13 more
doaj   +2 more sources

A rare concomitant tubercular and Fonsecaea pedrosoi fungal infection of the skull base. [PDF]

J Neurosci Rural Pract, 2012
ABSTRACTTuberculosis of the skull base and middle ear cavity is very rare. Infection with neurotropic fungi Fonsecaea pedrosoi is rare, which usually presents as brain abscess. We herein present an unusual case of concomitant tuberculosis and fungal (Fonsecaea pedrosoi) infections involving the middle ear cleft extending and destroying the ...
Suchanda B, Alugolu R, Purohit A, Lakshmi V, Sundaram C.   +4 more
europepmc   +3 more sources

Characterization of Fonsecaea pedrosoi melanin [PDF]

Journal of General Microbiology, 1991
The constituents of the melanin complex from mycelial forms of Fonsecaea pedrosoi were partially characterized. The pigment was mainly accumulated on large alkali-extractable, electron-dense cytoplasmic bodies (melanosomes) and, apparently, on the outer layer of the cell wall as external deposits within verrucose outgrowths.
C S, Alviano, S R, Farbiarz, W, De Souza, J, Angluster, L R, Travassos   +4 more
openaire   +2 more sources

The impact of AlphaFold Protein Structure Database on the fields of life sciences

PROTEOMICS, Volume 23, Issue 17, September 2023., 2023
Abstract Arguably, 2020 was the year of high‐accuracy protein structure predictions, with AlphaFold 2.0 achieving previously unseen accuracy in the Critical Assessment of Protein Structure Prediction (CASP). In 2021, DeepMind and EMBL‐EBI developed the AlphaFold Protein Structure Database to make an unprecedented number of reliable protein structure ...
Mihaly Varadi, Sameer Velankar
wiley   +1 more source

Fonsecaea Pedrosoi Skin Infection in a Dog [PDF]

Journal of Veterinary Diagnostic Investigation, 2008
Fonsecaea pedrosoi is the most common fungal agent associated with human chromoblastomycosis. In the current study, a phaeohyphomycotic condition of the skin caused by Fonsecaea pedrosoi is described in a dog.
Sreekumari, Rajeev, Gail, Clifton, Cindy, Watson, Debra, Miller   +3 more
openaire   +2 more sources

First case of Rhinocladiella mackenziei brain abscess in Turkey: Case report and review of the literature

Mycoses, Volume 66, Issue 9, Page 755-766, September 2023., 2023
Abstract Rhinocladiella mackenziei is a highly neurotropic fungus, mainly reported from the Middle East. However, in recent years, there have been some cases from outside this region. We described an additional fatal case of R. mackenziei cerebral infection for the first time from Turkey and made a literature review of all previously reported cases ...
Ilvana Caklovica Kucukkaya, Cafer Ikbal Gulsever, Ilyas Dolas, Gonca Erkose Genc, Mert Ahmet Kuskucu, Pulat Akin Sabanci, Zayre Erturan   +6 more
wiley   +1 more source

In vitro susceptibility testing of Fonsecaea pedrosoi to antifungals [PDF]

Revista do Instituto de Medicina Tropical de São Paulo, 1997
Based on the difficulties experienced in the treatment of chromoblastomycosis, 12 primary human isolates of F. pedrosoi, were tested for their in vitro susceptibility to various antimycotics. We adapted the recommendations of the NCCLS for yeasts and followed the indications for mold testing from other authors in order to determine their MIC’s and the ...
BEDOUT, Catalina de, GÓMEZ, Beatriz L., RESTREPO, Angela   +2 more
openaire   +4 more sources