In vitro susceptibility testing of Fonsecaea pedrosoi to antifungals [PDF]
Based on the difficulties experienced in the treatment of chromoblastomycosis, 12 primary human isolates of F. pedrosoi, were tested for their in vitro susceptibility to various antimycotics. We adapted the recommendations of the NCCLS for yeasts and followed the indications for mold testing from other authors in order to determine their MIC’s and the ...
BEDOUT, Catalina de +2 more
openaire +5 more sources
Prediction of itraconazole minimum inhibitory concentration for Fonsecaea pedrosoi using Fourier Transform Infrared Spectroscopy (FTIR) and chemometrics. [PDF]
Fonsecaea pedrosoi is one of the main agents of chromoblastomycosis, a chronic subcutaneous mycosis. Itraconazole (ITC) is the most used antifungal in its treatment, however, in vitro antifungal susceptibility tests are important to define the best ...
Alessandra Koehler +3 more
doaj +2 more sources
Phosphatase activity on the cell wall ofFonsecaeapedrosoi [PDF]
The activity of a phosphatase was characterized in intact mycelial forms of Fonsecaea pedrosoi, a pathogenic fungus that causes chromoblastomycosis. At pH 5.5, this fungus hydrolyzed p-nitrophenylphosphate (p-NPP) to p-nitrophenol (p-NP) at a rate of 12.78 +/- 0.53 nmol p-NP per h per mg hyphal dry weight.
Kneipp, L. F. +6 more
openaire +4 more sources
Introducción: Las queratitis micóticas son enfermedades agresivas, con secuelas que pueden llevar a discapacidad visual permanente. Objetivo: Describimos un caso de úlcera corneal por un agente infrecuente, Fonsecaea pedrosoi, resaltando el dificultoso ...
Claudia Martínez-Córdoba +2 more
doaj +2 more sources
HIV Aspartic Peptidase Inhibitors Modulate Surface Molecules and Enzyme Activities Involved with Physiopathological Events in Fonsecaea pedrosoi [PDF]
Fonsecaea pedrosoi is the main etiological agent of chromoblastomycosis, a recalcitrant disease that is extremely difficult to treat. Therefore, new chemotherapeutics to combat this fungal infection are urgently needed.
Vanila F. Palmeira +11 more
doaj +2 more sources
Molecular epidemiology of Fonsecaea pedrosoi using mitochondrial DNA analysis [PDF]
Restriction fragment length polymorphism (RFLP) of mitochondrial DNA (mtDNA) from 49 clinical Fonsecaea pedrosoi isolates (18 isolates from Japan, 17 from Madagascar, 7 from Argentina, 5 from Venezuela, 1 from Costa Rica and 1 unknown) was studied. The 49 isolates were composed of 20 isolates of Type 1, 16 of Type 2, 12 of Type 4 and 1 of a new mtDNA ...
M Miyaji, R Negroni, H Ishizaki
exaly +3 more sources
Chromoblastomycosis due to Fonsecaea pedrosoi: an old wine in a rare bottle
Chromoblastomycosis is a chronic subcutaneous mycosis commonly caused by Fonsecaea, Phialophora, and Cladophialophora spp. Out of these, Fonsecaea pedrosoi is the most common etiological agent, implicated in 70%–90% of the cases reported worldwide.
Sadia Khan +7 more
doaj +4 more sources
Single-cell RNA sequencing unravels T cell exhaustion underlying the chronicity of chromoblastomycosis [PDF]
IntroductionChromoblastomycosis (CBM) is a chronic, neglected tropical fungal infection. Its immunopathogenesis, particularly the mechanism underlying its chronicity, remains poorly understood.MethodsWe performed single-cell RNA sequencing (scRNA-seq) on
Kexin Lei +36 more
doaj +2 more sources
We report the isolation of Fonsecaea pedrosoi from thorns of the plant Mimosa pudica L. at the place of infection identified by one of our patients. Clinical diagnosis of chromoblastomycosis was established by direct microscopic examination and cultures ...
Claudio Guedes Salgado +6 more
doaj +1 more source
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin)
An experimental study was conducted between January 2002 and April 2003 for the detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin) in skin tests. A total of 194 subjects were attended by spontaneous demand at the Infectious and Parasitic Diseases outpatient clinic of the Federal University of Maranhão-UFMA and ...
Garcia Marques, Sirlei +5 more
core +5 more sources

