Melanin in
BMC Microbiology, 2010 Background The pathogenic fungus Fonsecaea pedrosoi constitutively produces the pigment melanin, an important virulence factor in fungi. Melanin is incorporated in the cell wall structure and provides chemical and physical protection for the fungus.
de Souza Wanderley +7 more
doaj +3 more sources
Chromoblastomycosis Caused by Fonsecaea pedrosoi. [PDF]
Ann Dermatol, 2011 We report herein a case of chromoblastomycosis caused by Fonsecaea (F.) pedrosoi in a 39-year-old male, who showed multiple, asymptomatic, scaly erythematous plaques on the left shin for 12 months. Histopathologically, chronic granulomatous inflammation and either sclerotic or muriform cells were observed.
Kim DM +6 more
europepmc +4 more sources
The Major Chromoblastomycosis Etiologic Agent Fonsecaea pedrosoi Activates the NLRP3 Inflammasome [PDF]
Frontiers in Immunology, 2017 Fonsecaea pedrosoi is the main etiologic agent of chromoblastomycosis (CBM), one of the most prevalent subcutaneous mycosis in tropical and subtropical countries.
Raffael Júnio Araújo de Castro +10 more
doaj +2 more sources
In Vitro Activities of Five Antifungal Drugs Against Conidia and Sclerotic Cells of Chromoblastomycosis Agent Fonsecaea spp. [PDF]
Microbiol ImmunolABSTRACT Chromoblastomycosis (CBM) is a chronic skin and subcutaneous infection mainly caused by Fonsecaea pedrosoi, a dematiaceous fungus with various morphotypes. Characteristic sclerotic cells—globe‐shaped, multiseptated and pigmented—are found in lesions of infected individuals, though their differentiation in the host remains poorly understood. To
Takahashi AB +6 more
europepmc +2 more sources
A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine [PDF]
Dermatology and Therapy, 2020 Patients with chromoblastomycosis (CBM) usually have a history of local skin damage related to outdoor activities, mainly manifested as chronic refractory proliferative pathologic changes.
Xu-Cheng Shen +7 more
doaj +2 more sources
Prediction of itraconazole minimum inhibitory concentration for Fonsecaea pedrosoi using Fourier Transform Infrared Spectroscopy (FTIR) and chemometrics. [PDF]
PLoS ONE, 2020 Fonsecaea pedrosoi is one of the main agents of chromoblastomycosis, a chronic subcutaneous mycosis. Itraconazole (ITC) is the most used antifungal in its treatment, however, in vitro antifungal susceptibility tests are important to define the best ...
Alessandra Koehler +3 more
doaj +2 more sources
Fonsecaea pedrosoi Sclerotic Cells: Secretion of Aspartic-Type Peptidase and Susceptibility to Peptidase Inhibitors [PDF]
Frontiers in Microbiology, 2018 Fonsecaea pedrosoi is a dematiaceous fungus and the main causative agent of chromoblastomycosis that is a chronic disease usually affecting the human skin and subcutaneous tissues, which causes deformations and incapacities, being frequently refractory ...
Vanila F. Palmeira +8 more
doaj +2 more sources
Widespread Verrucous Plaques of Chromoblastomycosis: A 12-Year Diagnostic Odyssey. [PDF]
Clin Case RepABSTRACT Chromoblastomycosis is a deep fungal infection of the skin and subcutaneous tissue. This case underscores the critical importance of thorough laboratory investigations, particularly histopathology, in chronic dermatological conditions that mimic other granulomatous diseases.
Shrestha E +3 more
europepmc +2 more sources
A Novel Hyphal Suspension Approach for MIC Testing of Mould Fungi. [PDF]
MycosesABSTRACT Background Filamentous fungi cause a wide range of superficial and invasive infections, and antifungal susceptibility assay is essential for guiding effective therapy. Standard broth microdilution methods rely on microconidia‐based inocula; however, many clinically important moulds produce insufficient microconidia due to intrinsic ...
Zheng H, Li D, Ge N, Mei H, Li X, Liu W.
europepmc +2 more sources
HIV Aspartic Peptidase Inhibitors Modulate Surface Molecules and Enzyme Activities Involved with Physiopathological Events in Fonsecaea pedrosoi [PDF]
Frontiers in Microbiology, 2017 Fonsecaea pedrosoi is the main etiological agent of chromoblastomycosis, a recalcitrant disease that is extremely difficult to treat. Therefore, new chemotherapeutics to combat this fungal infection are urgently needed.
Vanila F. Palmeira +11 more
doaj +2 more sources