Results 41 to 50 of about 425,645 (218)

Determination of 30 Kinds of Antiparasitic Drugs in Animal-derived Foods by QuEChERS-UPLC-MS/MS

Shipin gongye ke-ji
Objective: A method for determining the residues of 30 antiparasitic drugs in animal-derived food using ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was established.
Lifeng FENG, Qian HUANG, Mengwei YE, Yonghui HUANG, Yan HUANG, Haoxue LIN, Min LIANG, Hui XU   +7 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Complete Genome Sequence and Comparative Genomics of Acetobacter cerevisiae KSO5 (KACC 92352P) Provide Genome-Based Insights into Acid Tolerance

Microorganisms
Acetobacter cerevisiae KSO5 is an indigenous strain isolated from Korean fruit vinegar and is a potential starter candidate for vinegar fermentation.
Sun Hee Kim, Dae Gyu Choi, Dong Min Han, SeongEui Yoo, Jin Ju Park, Chan-Woo Kim, So-Young Kim   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Determination of the Concentrations of 176 Pharmaceutical and Personal Care Products in Drinking Water Samples by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry [PDF]

Shipin Kexue
A method for simultaneous determination of 176 pharmaceuticals and personal care products (PPCPs) in drinking water samples was established by combining solid-phase extraction (SPE) with ultra-high performance liquid chromatography-tandem mass ...
WU Shaoming, LIU Wenjing, DAI Ming, HE Menghang, CHEN Yankai, WANG Zheng, ZHAN Chongqing, OUYANG Liqun
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Simultaneous Determination of 28 Food-Derived Metabolic Modulators in Instant Foods by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry with Automatic Dispersive Solid Phase Extraction [PDF]

Shipin Kexue
In view of the contamination risk of food-derived metabolic modulators caused by factors such as their residues in food raw materials and their illegal addition in instant foods, as well as the limitations of existing detection technologies such as ...
HUANG Qian, FENG Lifeng, YE Mengwei, WANG Chun, HUANG Liqun, PAN Cheng
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source