Results 41 to 50 of about 450,993 (219)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
MicroorganismsAcetobacter cerevisiae KSO5 is an indigenous strain isolated from Korean fruit vinegar and is a potential starter candidate for vinegar fermentation.
Sun Hee Kim +6 more
doaj +1 more source
Determination of the Concentrations of 176 Pharmaceutical and Personal Care Products in Drinking Water Samples by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry [PDF]
Shipin KexueA method for simultaneous determination of 176 pharmaceuticals and personal care products (PPCPs) in drinking water samples was established by combining solid-phase extraction (SPE) with ultra-high performance liquid chromatography-tandem mass ...
WU Shaoming, LIU Wenjing, DAI Ming, HE Menghang, CHEN Yankai, WANG Zheng, ZHAN Chongqing, OUYANG Liqun
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Simultaneous Determination of 28 Food-Derived Metabolic Modulators in Instant Foods by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry with Automatic Dispersive Solid Phase Extraction [PDF]
Shipin KexueIn view of the contamination risk of food-derived metabolic modulators caused by factors such as their residues in food raw materials and their illegal addition in instant foods, as well as the limitations of existing detection technologies such as ...
HUANG Qian, FENG Lifeng, YE Mengwei, WANG Chun, HUANG Liqun, PAN Cheng
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Antibiotic Resistance in Acetic Acid Bacteria Originating from Vinegar
AntibioticsAcetic acid bacteria (AAB) are major contributors to the production of fermented vinegar, offering various cultural, culinary, and health benefits. Although the residual unpasteurized AAB after vinegar production are not pathogens, these are necessary ...
Sun-Hee Kim +6 more
doaj +1 more source