Results 61 to 70 of about 450,993 (219)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Determination of Selenium in Tea by Microwave Digestion-inductively Coupled Plasma Mass Spectrometry (ICP-MS) [PDF]

Chaye kexue
In order to improve the sensitivity and stability of microwave digestion-inductively coupled plasma mass spectrometry (ICP-MS), an accurate method for the determination of selenium in tea was established.
XU Wenqi
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Enhancing postharvest storage quality and cuticular wax composition of summer black grapes through preharvest calcium application

Food Chemistry: X
This study investigated the effects of preharvest calcium treatments at different developmental stages on the cuticular wax composition of Summer Black grapes and their correlation with fruit storage quality (4 ± 0.5 °C) and reactive oxygen species (ROS)
Yaoying Zeng, Hui Su, Le Xie, Yubo Xiong, Zhuojun Yu, Jiehai She, Kai Zhang, Hongyan Huo, Wei He, Wenhua Zhou   +9 more
doaj   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation

Food Science and Human Wellness
Alzheimer's disease (AD) is a neurodegenerative disorder associated with brain aging, and the accumulation of β-amyloid (Aβ) and hyperphosphorylated Tau proteins are key pathological features.
Yadan Zhang, Diya Xu, Xiaoyu Zhang, Wenhua Zhou, Lin Zhang, Qinlu Lin   +5 more
doaj   +1 more source

Determination of Illegally Added Digitalis Drugs in Health Foods by Ultra-high Performance Liquid Chromatography-Tandem Mass Spectrometry [PDF]

Shipin Kexue
A method for the determination of six illegally added digitalis drugs (methyldigoxin, digoxin, deslanoside, digitoxin, strophanthidin, lanatoside C) in health foods was established by ultra-high performance liquid chromatography-tandem mass spectrometry (
PAN Cheng, HUANG Qian, FU Minhao, LIN Bowei, LIAO Xiaolei, LIN Qin
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source