Results 81 to 90 of about 957,143 (265)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Food Bioactive Compounds and Their Interference in Drug Pharmacokinetic/Pharmacodynamic Profiles

Pharmaceutics, 2018
Preclinical and clinical studies suggest that many food molecules could interact with drug transporters and metabolizing enzymes through different mechanisms, which are predictive of what would be observed clinically.
Matteo Briguglio, Silvana Hrelia, Marco Malaguti, Loredana Serpe, Roberto Canaparo, Bernardo Dell’Osso, Roberta Galentino, Sara De Michele, Carlotta Zanaboni Dina, Mauro Porta, Giuseppe Banfi   +10 more
doaj   +1 more source

Relations Between Occurrence of the Risk of Food-Drug Interactions and Patients' Socio-Demographic Characteristics and Selected Nutrition Habits

, 2011
Relations Between Occurrence of the Risk of Food-Drug Interactions and Patients' Socio-Demographic Characteristics and Selected Nutrition Habits The objective of the study was to investigate the patients' exposure to food-drug interactions, and to ...
M. Jarosz, K. Wolnicka
semanticscholar   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

USE OF ANTI-INFECTIVE MEDICATIONS VIA THE GASTROSTOMY CATHETER: RECOMMENDATIONS FOR NURSING

Cogitare Enfermagem, 2018
Objective: to present specific recommendations in the preparation and administration of anti-infective medications via the gastrostomy catheter in the Emergency Unit of a University Hospital in the South of Brazil.
Moara Avila de Jesus Moreira, Paula Pereira de Figueiredo, Rosemary Silva da Silveira, Liziani Iturriet Avila, Bárbara Tarouco da Silva, Aline Martins Praxedes Silva   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Food and Drug Interactions

Journal of Lifestyle Medicine, 2017
Natural foods and vegetal supplements have recently become increasingly popular for their roles in medicine and as staple foods. This has, however, led to the increased risk of interaction between prescribed drugs and the bioactive ingredients contained ...
Jong Hwan Choi, C. Ko
semanticscholar   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Food interactions with tyrosine kinase inhibitors used to treat advanced renal cell carcinoma

Contemporary Oncology
Renal cancer accounts for approximately 4.4% of all malignant tumors worldwide. In the case of tumors limited to the kidney, the primary method of treatment is surgery.
Agata Sałek-Zań, Mirosława Püsküllüoğlu, Karolina Syrek-Kaplita, Tomasz Banaś   +3 more
doaj   +1 more source