Results 121 to 130 of about 4,652,448 (317)
Molecular Oncology, EarlyView.Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Molecular Oncology, EarlyView.Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Safety of Acheta domesticus powder as a Novel food pursuant to Regulation (EU) 2015/2283 [PDF]
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on Acheta (A.) domesticus powder as a novel food (NF) pursuant to Regulation (EU) 2015/2283.
EFSA Panel Nutr Novel Foods & Food Allergens NDA
core +1 more source
Actual lipid consumption in sports training. Functional role and importance in metabolism
ACROSSCurrently, many athletes, including coaches (except nutritionists), unilaterally evaluate the lipid component, considering it mainly a source of energy.
Victor MANOLACHI
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
2022 Global food report on food crises: Joint analysis for better decisions: Mid-year update [PDF]
According to the GRFC 2022 Mid-Year Update, the number of people in Crisis or worse (IPC/CH Phase 3 or above) or equivalent – that is the number of people requiring urgent humanitarian assistance – is forecast to reach up to 205.1 million in 45 of the 53
Rice, Brendan +3 more
core
The Allocation of Food to Food Banks
Journal of Political Economy, 2015 Food banks throughout the U.S. provide nutrition to the needy. Much of the food that is distributed through food banks often originates with donors large manufacturers or distributors far from those needy clients. How that food is distributed by Feeding America, a large not-for-profit, is the subject of this essay. In 2005, Feeding America transitioned
openaire +1 more source